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Our scientists show you what they are doing to advance safety assessment of chemicals without relying on animal testingdefault frame updated video

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The European Union Reference Laboratory for alternatives to animal testing (EURL-ECVAM) has been formally established in 2011, due to the increasing need for new methods to be developed and proposed for validation in the European Union. EURL ECVAM is hosted by the Joint Research Centre located in Ispra, Italy.

EURL ECVAM has a long tradition in the validation of methods which reduce, refine or replace the use of animals for safety testing and efficacy/potency testing of chemicals, biologicals and vaccines. Research laboratories are able to submit to EURL ECVAM for scientific validation the alternative methods to animal testing that they have developed.

EURL ECVAM also promotes the development and dissemination of alternative methods and approaches, their apEURL-ECVAMplication in industry and their acceptance by regulators.

The European Commission's involvement in activities targeted to the validation of alternative approaches to animal testing started in 1991, with the launch of ECVAM (the European Centre for the Validation of Alternative Methods), hosted by the Joint Research Centre. As from 2011, ECVAM's tasks are assigned to EURL ECVAM.Cell culture under sterile conditions-2

The menu on the left hand side of the page helps you browse through the main content sections of the EURL ECVAM web site.

To contact EURL ECVAM, please use this interactive form.

Photo: Cell culture under sterile conditions in the EURL ECVAM microbiology laboratory. Copyright EU 2012.

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highlights

Exploitation of Cell Transformation Assays for better in vitro carcinogenicity testing Exploitation of Cell Transformation Assays for better in vitro carcinogenicity testing - Sep 18, 2017 JRC scientists – in close collaboration with the Universities of Milan and Florence in Italy – investigated the relationship between increasing concentrations of two carcinogens, namely nickel chloride and benzopyrene, and specific features of cell transformation assays (CTAs). This work paves the way for improved exploitation of CTAs for carcinogenicity testing.
A modelling approach to avoid chronic fish toxicity tests A modelling approach to avoid chronic fish toxicity tests - Sep 07, 2017 The European Union Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) of the European Commission's Joint Research Centre has published an article on the possible use of a simple modelling approach to avoid the need for chronic fish testing in chemical risk assessment.
Improved performance of in vitro genotoxicity testing? Improved performance of in vitro genotoxicity testing? - Aug 29, 2017 JRC scientists reviewed the recent activities and achievements in the area of genotoxicity testing with the conclusion that the availability of improved tests and strategies can significantly contribute to the reduction and potential replacement of animals used for regulatory testing.
Review of state-of-the-science of non-animal alternatives for acute systemic toxicity testing Review of state-of-the-science of non-animal alternatives for acute systemic toxicity testing - Aug 09, 2017 The JRC participated along with other international experts in the review of current approaches for acute systemic toxicity testing
European drive to validate in vitro methods for the detection of thyroid disruptors European drive to validate in vitro methods for the detection of thyroid disruptors - Jul 07, 2017 The JRC's EURL ECVAM has launched a validation study to assess in vitro methods for the detection of chemicals which disrupt thyroid function.
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calls

Call for Tender - Review of non-animal methods used in disease research Call for Tender - Review of non-animal methods used in disease research The JRC's EURL ECVAM has launched a study to collect and describe non-animal methods being used for basic and applied research into neurodegenerative, respiratory tract and cardiovascular diseases, and breast cancer.
Call for experts to serve on EURL ECVAM's Scientific Advisory Committee (ESAC) Call for experts to serve on EURL ECVAM's Scientific Advisory Committee (ESAC) The European Union Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) is renewing membership of its EURL ECVAM Scientific Advisory Committee (ESAC). Interested scientific experts who satisfy the eligibility criteria and who possess the relevant competences are invited to apply (Deadline 31st January 2017).
EURL ECVAM extends the EU Network of Laboratories for the Validation of Alternative Methods (EU-NETVAL) EURL ECVAM extends the EU Network of Laboratories for the Validation of Alternative Methods (EU-NETVAL) Supporting the validation and implementation of in vitro methods for regulatory use
Horizon 2020 Call on New approaches to improve predictive human safety testing Horizon 2020 Call on New approaches to improve predictive human safety testing The role of JRC / EURL ECVAM in cooperating with successful consortia
Call for expressions of interest - EURL ECVAM Stakeholder forum (ESTAF) Open Invitation addressed to stakeholder organisations
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multimedia

Toxicological Testing of Chemicals & EURL ECVAM Toxicological Testing of Chemicals & EURL ECVAM Faces of Science - showcasing the human face of the scientific advice supporting EU policy. Maurice Whelan at the Joint Research Centre, the European Commission's in-house science service, presents the Toxicological Testing of Chemicals and EURL ECVAM
New EURL ECVAM video explains the validation process of alternative methods (in Italian) New EURL ECVAM video explains the validation process of alternative methods (in Italian) This video presents the European Union Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) and explains the validation process of alternative methods