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Our scientists show you what they are doing to advance safety assessment of chemicals without relying on animal testingdefault frame updated video

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The European Union Reference Laboratory for alternatives to animal testing (EURL-ECVAM) has been formally established in 2011, due to the increasing need for new methods to be developed and proposed for validation in the European Union. EURL ECVAM is hosted by the Joint Research Centre located in Ispra, Italy.

EURL ECVAM has a long tradition in the validation of methods which reduce, refine or replace the use of animals for safety testing and efficacy/potency testing of chemicals, biologicals and vaccines. Research laboratories are able to submit to EURL ECVAM for scientific validation the alternative methods to animal testing that they have developed.

EURL ECVAM also promotes the development and dissemination of alternative methods and approaches, their apEURL-ECVAMplication in industry and their acceptance by regulators.

The European Commission's involvement in activities targeted to the validation of alternative approaches to animal testing started in 1991, with the launch of ECVAM (the European Centre for the Validation of Alternative Methods), hosted by the Joint Research Centre. As from 2011, ECVAM's tasks are assigned to EURL ECVAM.Cell culture under sterile conditions-2

The menu on the left hand side of the page helps you browse through the main content sections of the EURL ECVAM web site.

To contact EURL ECVAM, please use this interactive form.

Photo: Cell culture under sterile conditions in the EURL ECVAM microbiology laboratory. Copyright EU 2012.

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highlights

JRC meets with OECD experts to define good practices for in vitro methods JRC meets with OECD experts to define good practices for in vitro methods - Mar 24, 2017 On the 23rd and 24th of March the JRC's EU Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) hosted a meeting with OECD experts to discuss the draft of a guidance document on Good In Vitro Method Practice (GIVIMP). This GIVIMP document would serve as a technical guidance on good scientific and quality practices to support the regulatory human safety assessment of chemicals using in vitro methods.
JRC supports the use of stem cells for non-animal approaches to regulatory toxicity assessment JRC supports the use of stem cells for non-animal approaches to regulatory toxicity assessment - Feb 23, 2017 New publication summarises the outcome of a workshop organised by the European Partnership of Alternatives to Animal Testing (EPAA) on the use of stem cell-derived in vitro test systems in toxicology.
Reducing animal testing through better knowledge sharing Reducing animal testing through better knowledge sharing - Feb 20, 2017 The JRC has carried out a study of available knowledge on the replacement, reduction and refinement (the 3Rs) of animal procedures used in research and testing to understand how supply of such knowledge can better meet demand. Findings show that although much 3Rs knowledge exists, its sharing can be improved through better coordination, communication and outreach, and by more emphasis on targeted education and training initiatives.
A 21st-century roadmap for biomedical research A 21st-century roadmap for biomedical research - Feb 15, 2017 JRC scientist contributes to the definition of a 21st-century roadmap for biomedical research which proposes the use of human-specific models and innovative in vitro technologies instead of animals.
JRC hosts the VAC2VAC workshop on validation of non-animal methods for quality control of vaccines JRC hosts the VAC2VAC workshop on validation of non-animal methods for quality control of vaccines - Feb 10, 2017 The JRC's EU Reference Laboratory for alternatives to animal testing (EURL ECVAM) organised this workshop with VAC2VAC partners from the 30th January to the 1st February 2017 to discuss ways of improving multi-centre validation studies and making use of the data generated for product-specific validation purposes.
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events

JRC Summer School on Alternative Approaches for Risk assessment  - THE PATH FROM SCIENCE TO PROTECTION OF HUMAN HEALTH AND THE ENVIRONMENT JRC Summer School on Alternative Approaches for Risk assessment - THE PATH FROM SCIENCE TO PROTECTION OF HUMAN HEALTH AND THE ENVIRONMENT - May 16, 2017 - May 19, 2017 The JRC's Chemical Safety and Alternative Methods Unit, which incorporates the EU Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM), is organising a JRC Summer School from the 16-19 May 2017, at the JRC Ispra site, on the topic of "Alternative Approaches for Risk Assessment". The overall aim is to provide comprehensive training on state-of-the-art alternative (non-animal) approaches to predictive toxicology and to promote their use within modern chemical risk assessment practice.
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calls

Call for experts to serve on EURL ECVAM's Scientific Advisory Committee (ESAC) Call for experts to serve on EURL ECVAM's Scientific Advisory Committee (ESAC) The European Union Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) is renewing membership of its EURL ECVAM Scientific Advisory Committee (ESAC). Interested scientific experts who satisfy the eligibility criteria and who possess the relevant competences are invited to apply (Deadline 31st January 2017).
EURL ECVAM extends the EU Network of Laboratories for the Validation of Alternative Methods (EU-NETVAL) EURL ECVAM extends the EU Network of Laboratories for the Validation of Alternative Methods (EU-NETVAL) Supporting the validation and implementation of in vitro methods for regulatory use
Horizon 2020 Call on New approaches to improve predictive human safety testing Horizon 2020 Call on New approaches to improve predictive human safety testing The role of JRC / EURL ECVAM in cooperating with successful consortia
Call for expressions of interest - EURL ECVAM Stakeholder forum (ESTAF) Open Invitation addressed to stakeholder organisations
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multimedia

Toxicological Testing of Chemicals & EURL ECVAM Toxicological Testing of Chemicals & EURL ECVAM Faces of Science - showcasing the human face of the scientific advice supporting EU policy. Maurice Whelan at the Joint Research Centre, the European Commission's in-house science service, presents the Toxicological Testing of Chemicals and EURL ECVAM
New EURL ECVAM video explains the validation process of alternative methods (in Italian) New EURL ECVAM video explains the validation process of alternative methods (in Italian) This video presents the European Union Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) and explains the validation process of alternative methods