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Workshop on "Advancing Adverse Outcome Pathways for Integrated Toxicology and Regulatory Applications"

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Mar 19, 2014
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Co-organised by JRC's IHCP and IES, Environment Canada, US EPA, US ERDC & academic organisations from USA, Switzerland and Norway

A workshop on "Advancing Adverse Outcome Pathways for Integrated Toxicology and Regulatory Applications" was held in Somma Lombardo (Italy) on 2-7 March 2014. The event was hosted by two Institutes of the EC Joint Research Centre - IHCP - Institute for Health and Consumer Protection and IES - Institute for Environment and Sustainability, which co-organised the event together with Environment Canada, US Environment Protection Agency, US Engineer Research and Development Center, academic organisations from USA, Switzerland and Norway.

The workshop brought more than 50 experts from regulatory agencies, academia and industry together to discuss the Adverse Outcome Pathway concept as a framework to characterise, organise, and define predictive relationships between measurable key events that reflect the progression from a chemical-induced perturbation to an adverse outcome considered relevant to regulatory decision-making. 

The workshop progressed ongoing efforts (e.g. at the level of the OECD) and provided consideration and expert opinion on the critical next steps required to advance the use and acceptance of the AOP framework to support integrated toxicology and regulatory decision-making. In addition, discussions fed into further refinements of the AOP wiki - an IT system jointly led by the EC Joint Research Centre and the US Environmental Protection Agency for the purpose of the OECD programme on the development of AOPs, which was first released in August 2013. The AOP wiki is intended to facilitate the development and evaluation of Adverse Outcome Pathways, providing developers with a structured wiki type environment to capture the scientific information in a user-friendly manner in accordance with the elements of an AOP.

The discussions, conclusions and recommendations of the workshop will be published in peer reviewed journals.

Image: AOP template.