EURL ECVAM Latest News

Human relevant in-vitro models for developmental neurotoxicity testing

Human relevant in-vitro models for developmental neurotoxicity testing

JRC scientists have shown that human induced pluripotent stem cell-derived neurons are suitable non-animal models for testing neurotoxicity during brain development. The study revealed that long term exposure to the pesticide rotenone induces oxidative stress and can trigger neuronal cell death.

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Knowledge sharing on in vitro methods: meeting of the EU Network of Laboratories for the Validation of Alternative Methods (EU-NETVAL)

Knowledge sharing on in vitro methods: meeting of the EU Network of Laboratories for the Validation of Alternative Methods (EU-NETVAL)

EU-NETVAL is a large network of highly qualified test facilities across Europe, coordinated by the Joint Research Centre to support the in vitro method validation process. The annual meeting of this network took place on the 10-11th October 2017 to facilitate the sharing of expertise and practical knowledge for the advancement of in vitro methods to improve safety assessment and avoid animal testing.

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Recommendations to delete or replace animal tests for quality control of biologicals

Recommendations to delete or replace animal tests for quality control of biologicals

International experts, including JRC scientists, recommend as outcome of special workshop the deletion or replacement of specific animal tests for the quality control of medicinal products, in particular biologicals (e.g. hormones, vaccines, immunoglobulins, blood products).

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In vitro biomarkers to screen chemicals for potential cardiotoxicity in humans

In vitro biomarkers to screen chemicals for potential cardiotoxicity in humans

JRC scientists have studied in vitro short and long-term effects of a model cardiotoxicant on mitochondrial function of human cardiomyocytes with the ultimate aim of defining biomarkers that could help in predicting potential cardiotoxic effects induced by chemicals upon acute and repeat dosing.

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Expert workshop to capture inflammatory processes within the Adverse Outcome Pathway framework

Expert workshop to capture inflammatory processes within the Adverse Outcome Pathway framework

The European Commission’s Joint Research Centre (JRC) in Ispra hosted a two day workshop on 27-28th September 2017 to address how the complex and dynamic processes of inflammation could be integrated within the context of the Adverse Outcome Pathway (AOP) framework. This will contribute to the ongoing work to accelerate progress in the development of non-animal test methods.

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Review of computational models for the safety assessment of nanomaterials

Review of computational models for the safety assessment of nanomaterials

JRC scientists have reviewed the current status and potential applicability of computational methods for predicting the properties of engineered nanomaterials, especially in view of EU chemicals legislation (in particular REACH). The outcome of the study revealed that considerable scientific progress has been made, although challenges remain in translating these developments into regulatory practice.

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The JRC to support a new Austrian platform for promoting non-animal approaches

The JRC to support a new Austrian platform for promoting non-animal approaches

In a recent workshop Austria has announced plans to establish a national platform for the development of in vitro and in silico methods to assess the safety of chemicals. The Joint Research Centre will collaborate and support the implementation of this platform.

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Supporting chemical safety assessment with computational models of the skin

Supporting chemical safety assessment with computational models of the skin

JRC scientists contributed to the review of in silico models that have been developed for the prediction of skin permeability. Such models are relevant for the implementation of EU legislation on chemicals that strongly recommend or require the use of alternative approaches to animal studies.

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Exploitation of Cell Transformation Assays for better in vitro carcinogenicity testing

Exploitation of Cell Transformation Assays for better in vitro carcinogenicity testing

JRC scientists – in close collaboration with the Universities of Milan and Florence in Italy – investigated the relationship between increasing concentrations of two carcinogens, namely nickel chloride and benzopyrene, and specific features of cell transformation assays (CTAs). This work paves the way for improved exploitation of CTAs for carcinogenicity testing.

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A modelling approach to avoid chronic fish toxicity tests

A modelling approach to avoid chronic fish toxicity tests

The European Union Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) of the European Commission's Joint Research Centre has published an article on the possible use of a simple modelling approach to avoid the need for chronic fish testing in chemical risk assessment.

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