EURL ECVAM Latest News

Human stem cell models for neurotoxicity screening

Human stem cell models for neurotoxicity screening

JRC scientists have shown human induced pluripotent stem cell (hiPSC) to be a promising in vitro model for neurotoxicity testing. These stem cell-based systems offer an innovative human-relevant alternative to traditional animal tests that can improve the efficacy of drug discovery and support safety assessment.

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Two new guidelines for the reduction of animal tests for quality control of veterinary vaccines

Two new guidelines for the reduction of animal tests for quality control of veterinary vaccines

JRC scientists supported the development of two guidelines released by the International Cooperation on Harmonisation of Technical Requirements for Registration of Veterinary Medicinal Products (VICH) on the harmonisation of criteria to waive target animal batch safety tests for inactivated and live veterinary vaccines. Their implementation (from May 2018 onwards) is a major step towards international harmonisation and will reduce the number of animals used for batch release testing. The JRC's EU Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) has been working on behalf of EMA with VICH experts on the development of these guidelines.

Two new guidelines for the reduction of animal tests for quality control of veterinary vaccines - Read More…

JRC Summer School on Alternative Approaches for Risk Assessment

JRC Summer School on Alternative Approaches for Risk Assessment

From 16 to 19 May, the JRC hosted in Ispra (Italy) 101 postgraduate students and early-career scientists from 29 countries worldwide for the JRC Summer School on Alternative Approaches for Risk Assessment.

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Reducing animal testing while improving the safety assessment of chemicals for skin allergies

Reducing animal testing while improving the safety assessment of chemicals for skin allergies

The JRC's European Union Reference Laboratory for alternatives to animal testing (EURL ECVAM) has published its recommendation on the use of non-animal approaches for skin sensitisation (allergy) testing. This document builds on the progress made in the area since the publication of the EURL ECVAM strategy in 2013 and provides EURL ECVAM views on the latest two methods for skin sensitisation, the LuSens and the U-SENS™, peer-reviewed by the EURL ECVAM Scientific Advisory Committee (ESAC) and on Defined Approaches which are based on the integration of different kinds of non-animal data.

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JRC hosts a meeting to strengthen its collaboration with the European Food Safety Authority (EFSA)

JRC hosts a meeting to strengthen its collaboration with the European Food Safety Authority (EFSA)

On 5th April JRC-Ispra hosted a delegation from EFSA to discuss specific topics of common interest in the area of risk assessment related to chemicals.

JRC hosts a meeting to strengthen its collaboration with the European Food Safety Authority (EFSA) - Read More…

Understanding nanomaterial toxicity by leveraging mechanistic information on chemicals

Understanding nanomaterial toxicity by leveraging mechanistic information on chemicals

JRC scientists carried out a study illustrating how the mechanisms of nanomaterial toxicity can be better understood by exploiting the broader body of mechanistic information on chemicals in general.

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The pathway from liver injury to liver fibrosis

The pathway from liver injury to liver fibrosis

JRC scientists have used an Adverse Outcome Pathway approach to explain how some chemicals can potentially cause liver fibrosis in humans in order to support the development of non-animal approaches to chemical safety assessment.

The pathway from liver injury to liver fibrosis - Read More…

EURL ECVAM is inviting public comments on its draft Recommendation on the use of non-animal approaches for skin sensitisation testing

The European Union Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) is inviting public comments on its latest draft Recommendation concerning the use of non-animal approaches for skin sensitisation testing.

EURL ECVAM is inviting public comments on its draft Recommendation on the use of non-animal approaches for skin sensitisation testing - Read More…

JRC meets with OECD experts to define good practices for in vitro methods

JRC meets with OECD experts to define good practices for in vitro methods

On the 23rd and 24th of March the JRC's EU Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) hosted a meeting with OECD experts to discuss the draft of a guidance document on Good In Vitro Method Practice (GIVIMP). This GIVIMP document would serve as a technical guidance on good scientific and quality practices to support the regulatory human safety assessment of chemicals using in vitro methods.

JRC meets with OECD experts to define good practices for in vitro methods - Read More…

JRC supports the use of stem cells for non-animal approaches to regulatory toxicity assessment

JRC supports the use of stem cells for non-animal approaches to regulatory toxicity assessment

New publication summarises the outcome of a workshop organised by the European Partnership of Alternatives to Animal Testing (EPAA) on the use of stem cell-derived in vitro test systems in toxicology.

JRC supports the use of stem cells for non-animal approaches to regulatory toxicity assessment - Read More…

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