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The 3Rs in the quality control of human vaccines: EURL ECVAM releases summary of ongoing projects

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Jan 20, 2016
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The European Union Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) of the European Commission's Joint Research Centre has just released its report summarising ongoing projects to replace, reduce and refine the use of animals in the quality control of human vaccines.

Vaccines are recognised as a highly cost effective tool for preventing infectious diseases. They are derived from biological sources and due to the complexity of composition and heterogeneity of products, vaccine lots undergo legally required quality control before they are released.

The focus of the EURL ECVAM report is on methods for quality control (e.g. safety, potency) of established vaccines such as diphtheria, tetanus, pertussis and rabies vaccines, where despite the progress achieved over the last decades, still many animals are used for the lot release. The report further highlights ongoing projects related to the use of the consistency approach and its potential of further reducing animal use.

The EURL ECVAM report: "Replacement, Reduction and Refinement of Animal Testing in the Quality Control of Human Vaccines - Brief description of ongoing projects"