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Exploitation of Cell Transformation Assays for better in vitro carcinogenicity testing - Sep 18, 2017
Exploitation of Cell Transformation Assays for better in vitro carcinogenicity testing
JRC scientists – in close collaboration with the Universities of Milan and Florence in Italy – investigated the relationship between increasing concentrations of two carcinogens, namely nickel chloride and benzopyrene, and specific features of cell transformation assays (CTAs). This work paves the way for improved exploitation of CTAs for carcinogenicity testing.
Updated list of alternative test methods submitted to EURL ECVAM - Jun 20, 2014
Updated list of alternative test methods submitted to EURL ECVAM
New version, June 2014
Located in Test Method Submission
JRC launches the EURL ECVAM Genotoxicity & Carcinogenicity Database of Ames positive chemicals - Dec 12, 2014
JRC launches the EURL ECVAM Genotoxicity & Carcinogenicity Database of Ames positive chemicals
A new JRC resource for predictive toxicology
Located in news
The reference Carcinogenicity Genotoxicity eXperience (CGX) dataset now hosted by JRC - Jan 19, 2015
The reference Carcinogenicity Genotoxicity eXperience (CGX) dataset now hosted by JRC
Available from the JRC/EURL ECVAM website
Located in Latest News
EURL ECVAM Genotoxicity & Carcinogenicity Consolidated Database of Ames Positive Chemicals
Located in Databases
Improved performance of in vitro genotoxicity testing? - Aug 29, 2017
Improved performance of in vitro genotoxicity testing?
JRC scientists reviewed the recent activities and achievements in the area of genotoxicity testing with the conclusion that the availability of improved tests and strategies can significantly contribute to the reduction and potential replacement of animals used for regulatory testing.
Assessing performance of new or improved genotoxicity tests: EURL ECVAM publishes an updated recommended list of reference chemicals - Dec 21, 2015
Assessing performance of new or improved genotoxicity tests: EURL ECVAM publishes an updated recommended list of reference chemicals
Reference chemical selection is a key step in the development, optimisation and validation of alternative test methods. In light of newly available data, the JRC's European Union Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM), supported by a group of experts, has revised its recommended list of genotoxic and non-genotoxic chemicals for assessing the performance of new or improved in vitro genotoxicity test methods.