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COSMOS Webinar: Automated in silico tools for in vitro to in vivo extrapolation - Apr 13, 2015
COSMOS Webinar: Automated in silico tools for in vitro to in vivo extrapolation
Information on computational tools which could be used to support chemical risk assessment
Located in news / news_docs
Computational modelling of estrogen active substances: results of a large-scale international research project - Nov 16, 2016
Computational modelling of estrogen active substances: results of a large-scale international research project
The JRC contributed to a large-scale modelling project led by the US Environmental Protection Agency (EPA) that demonstrated the usefulness of computational models in screening thousands of environmental chemicals for their ability to bind to the estrogen receptor. Chemicals that bind to the estrogen receptor may interfere with the biological effects of the natural hormone estrogen, potentially leading to adverse effects on both humans and wildlife.
Supporting chemical safety assessment with computational models of the skin - Sep 22, 2017
Supporting chemical safety assessment with computational models of the skin
JRC scientists contributed to the review of in silico models that have been developed for the prediction of skin permeability. Such models are relevant for the implementation of EU legislation on chemicals that strongly recommend or require the use of alternative approaches to animal studies.
Review of computational models for the safety assessment of nanomaterials - Oct 02, 2017
Review of computational models for the safety assessment of nanomaterials
JRC scientists have reviewed the current status and potential applicability of computational methods for predicting the properties of engineered nanomaterials, especially in view of EU chemicals legislation (in particular REACH). The outcome of the study revealed that considerable scientific progress has been made, although challenges remain in translating these developments into regulatory practice.
Biologically based mathematical models in toxicology: current use and regulatory acceptance - Nov 14, 2017
Biologically based mathematical models in toxicology: current use and regulatory acceptance
Scientists from the JRC and US Environmental Protection Agency examined how and to what extent mathematical models of biological organisms are used in toxicology, and identified a number of challenges that need to be overcome for wider use and regulatory acceptance of these non-animal approaches.
OECD QSAR Toolbox and read-across - First free REACH webinar - Oct 22, 2014
OECD QSAR Toolbox and read-across - First free REACH webinar
Updated information on alternative methods and testing strategies that could be used to meet REACH information requirements on aspects of toxicological hazard of registered chemicals
Located in news
Predictive Toxicology
Located in Laboratories & Research Areas
JRC scientific activities in support of chemicals legislation presented to PlasticsEurope Main Food Contact Committee - Oct 26, 2011
JRC scientific activities in support of chemicals legislation presented to PlasticsEurope Main Food Contact Committee
Use of JRC software Toxtree
Located in Laboratories & Research Areas / Predictive Toxicology
JRC researchers develop a predictive tool for assessing human bioaccumulative potential - Dec 02, 2011
JRC researchers develop a predictive tool for assessing human bioaccumulative potential
Located in Laboratories & Research Areas / Predictive Toxicology
15th International Workshop on Quantitative Structure-Activity Relationships (QSAR2012) - Jun 18, 2012 - Jun 22, 2012
15th International Workshop on Quantitative Structure-Activity Relationships (QSAR2012)
Focus: Environmental and Health Sciences
Located in Laboratories & Research Areas / Predictive Toxicology