OECD publishes two Guidance Documents on integrated non-animal approaches to chemical safety assessment

The OECD has published two Guidance Documents (GDs) on the reporting of what are termed "Defined Approaches" which are based on the integration of different kinds of non-animal data derived for example from their physicochemical properties, computational modelling or in vitro methods. Defined approaches are emerging in areas of toxicology where a combination of two or more non-animal methods is required to provide a sufficient level of information to make regulatory safety decisions about chemicals.