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Alternative approaches to mammalian acute systemic toxicity testing - Fifth free REACH seminar (one of six)

Event details
Mar 05, 2015
from 04:00 PM to 05:00 PM
The web
Organizer: Chemical Watch & the PETA International Science Consortium, Ltd.

Updated information on alternative methods and testing strategies that could be used to meet REACH information requirements on aspects of toxicological hazard of registered chemicals

This is the fifth of a free webinar series of six, running from October, 22, 2014 to April 2015.
The seminars, co-organised by Chemical Watch (CW) and the PETA International Science Consortium, Ltd, will be of interest to industry toxicologists, those registering chemicals for the first time, companies who would like to know more about validated non-animal tests that are available and how companies are using them and REACH consultants. See info on the full series.

Four of these seminars, including this one, are held or co-held by EURL ECVAM scientists.

Webinar 5 of 6: Alternative Approaches to Mammalian Acute Systemic Toxicity Testing
March 5, 2015 
4pm- 5pm GMT/11am -12pm US EST


Dr. Pilar Prieto, EURL ECVAM
Dr. Lawrence Milchak, 3M 


Dr. Pilar Prieto will present on EURL ECVAM’s recently released strategy to replace, reduce and refine the use of animals in the assessment of acute mammalian systemic toxicity. The strategy highlights the importance of developing adverse outcome pathways (AOPs) and integrated approaches to testing and assessment (IATA) related to acute systemic toxicity. It also discusses improvements in the predictability of the 3T3 NRU assay, development of additional in vitro and in silicoapproaches, waiving acute toxicity testing based on e.g., repeated dose data, refinement of in vivo studies, and provides a framework for prioritizing the alternative methods that have been submitted to EURL ECVAM for validation. Following Dr. Prieto’s talk, Dr. Lawrence Milchak from 3M will speak to industry experiences on the use of alternative strategies to meet acute toxicity testing requirements.

More general information on the future webinars and live recordings of the previous ones on the PETA International Science Consortium, Ltd, web site.