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'Tools for Innovation', presentation by J. Kreysa to EPAA Annual Conference 2011

News details
Nov 22, 2011
J. Kreysa (JRC-IHCP)

Held in Brussels on 09.11.2011

A presentation by Joachim Kreysa (JRC-IHCP, Head of Unit, 'Validation of Alternative Methods') to the EPAA Annual Conference 2011 - ITS (Integrating Testing Strategies) held in Brussels on 9 November 2011 is now available on the EPAA web site:

pdf icon "Tools for Innovation - Serving the 3Rs as well as safety and business".

A synthesis is provided below.

The assessment of toxicity effects on complex biological and ecological systems requires innovation:

  • Basic research: to understand “normal” system behavior and how chemical insult can disturb it

  • Translational R&D: to translate understanding into test methods that are reliable (i.e. deliver reproducible results); relevant (i.e. provide info useful for assessing risks) and affordable (i.e. have reasonable cost and duration)

  • Validation: to efficiently confirm reliability & relevance, win-win for data-producer and -user, and to promote the use of functioning/valid methods.

EPAA's tools for innovation consist in:

  • a platform on 3Rs ('Replace, Reduce, Refine') in Regulation (where risk assessors and managers meet industry and science to discuss and solve bottlenecks)

  • a platform on Science (where basic/applied R&D meets risk assessors to identify key topics - integrated by workshops, seminars & science award for projects promising significant 3Rs impact)

  • a platform on Communication (where information provider meet information user)

The EPAA Market Place concept concerns all three platforms, where information-supply meets information-demand.
Thematic reviews provide concise, verified information on existing alternative approaches for safety testing, their potential and limitations.

The first topic for 2010/2011 is reproductive toxicity; next topic is still open but will be identified soon.


The European Partnership for Alternative Approaches to Animal Testing (EPAA) is a joint initiative from the European Commission, European trade associations from seven industry sectors and individual companies (see partners here). It was launched in November 2005 with the purpose to promote the development and implementation of new 3Rs methods (replace, reduce, refine) and modern alternative approaches in the field of safety testing.