JRC launches the EURL ECVAM Genotoxicity & Carcinogenicity Database of Ames positive chemicals
|Dec 12, 2014|
|Contact: EURL ECVAM|
A new JRC resource for predictive toxicology
The EURL ECVAM Genotoxicity & Carcinogenicity Consolidated database is built on curated genotoxicity and carcinogenicity data for 726 Ames positive chemicals compiled from a variety of sources and is intended to aid in the development and evaluation of alternative approaches to animal testing. It has been developed by EURL ECVAM (the European Union Reference Laboratory for Alternative to Animal Testing), part of the European Commission Joint Research Centre.
The generation of such a consolidated database on genotoxicity and carcinogenicity has been demanding in terms of time and effort in order to extract relevant data spread across several databases and to compile them in a harmonised format. Moreover, inconsistencies (e.g. contradictory data derived from different sources) and poor data quality needed to be addressed through rigorous curation which included expert peer review. This investment has led to the public release of a powerful resource for developing and evaluating alternative approaches to animal testing for genotoxicity and carcinogenicity assessment of chemicals.
- EURL ECVAM strategy aimed at avoiding and reducing animal use in genotoxicity testing
- EURL ECVAM workshop report on 'How can in vitro mammalian cell genotoxicity tests reduce the need for in vivo follow-up testing with compounds positive in the Ames test?'
Image: Composition of a) Bacterial isolation onto plate, b) Karyotype, c) DNA damage during replication; all reproduced from 'Servier Medical Art' by Servier (licensed under a Creative Commons Attribution 3.0 Unported License).