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Republic of Korea's Centre for the Validation of Alternative Methods joins the International Cooperation on Alternative Test Methods
On 8 March 2011, the Republic of Korea became the fifth member of the International Cooperation on Alternative Test Methods (ICATM).
Alternative Testing Strategies: launch of AXLR8 Progress Report 2010
The EU-sponsored coordination action project AXLR8 (pronounced “accelerate”), aimed at finding alternatives to animal research, launched the report at the EPAA annual conference, held on 30th November 2010 in Brussels.
New Directive on the protection of animals used for scientific purposes
Directive 2010/63/EU
EPAA Thematic Reviews
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Alternative tests methods in IHCP © EC 2010
Leaflet on 'Alternative methods to animal testing'
Target: general public.
ECVAM Technical Report on the Status of Alternative Methods for Cosmetics Testing (2008-2009)
A report prepared in the framework of Directive 2003/15/EC (7th Amendment to the Cosmetics Directive). JRC58991 - EUR 24413 EN - ISBN 978-92-79-16021-9 - ISSN 1018-5593 - DOI 10.2788/99101 Luxembourg: Publications Office of the EU © European Union, 2010
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Meeting of the ECVAM Scientific Advisory Committee (ESAC)
Activities of ECVAM (the European Centre for the Validation of Alternative Methods)
ICATM meeting
ICATM (International Collaboration on Alternative Test Methods) framework
Alternative Testing Strategies - 2008 Report - Replacing, reducing and refining use of animals in research
Edited by Charles Kessler - Directorate-General for Research - Life Sciences, Genomics and Biotechnology for Health - European Commission, 2008 - EUR 22846
Alternative Testing Strategies Progress report 2009. Replacing, Reducing And Refining Use Of Animals In Research.
Genomics & Biotechnology. Eur 23886 - Luxembourg: OPOCE, 2009 ISBN 978-92-79-11949-1 doi 10.2777/21412 ISSN 1018-5593 © European Communities, 2009
Results of ECVAM Prevalidation Study of Three Cell Transformation Assays
The European Centre for the Validation of Alternative Methods (ECVAM) hosted by the JRC-IHCP has recently conducted a prevalidation study of three cell transformation assays (CTA) for carcinogenicity testing.
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"Reduction and Refinement": EPAA 2010 Annual Conference Report now available
Outcome of the 6th EPAA Annual Conference (Brussels, November 2010)
Meeting of the ECVAM Scientific Advisory Committee (ESAC)
ESAC opinion discussed (prevalidation of three protocols of an in vitro cell transformation assay)
Image JPEG image Signature of the agreement
Signature of the agreement
Application of micro-electrode arrays (MEAs) as an emerging technology for developmental neurotoxicity testing
Evaluation of domoic acid-induced effects in primary cultures of rat cortical neurons on the critical developmental processes of central nervous system.
Report: Alternative (non-animal) methods for cosmetics testing: current status and future prospects - 2010
The expert report published as a series of scientific articles in a peer-reviewed journal, highlights the most important findings of the experts and will be an important input for the Commission's report to the Parliament expected in mid-2011.
report_2010
Updated version of Report "Alternative (non-animal) methods for cosmetics testing: current status and future prospects - 2010"
Complete with references to journal issue, volume and page numbers.
Alternative testing methods-ECVAM: meetings of PARERE network and ESTAF
26.05.2011 and 27.05.2011 in JRC Ispra, Varese
FAQs - Alternative (Non-Animal) Methods for Cosmetics Testing
Report explained: "Alternative (Non-Animal) Methods for Cosmetics Testing: Current Status and Future Prospects – 2010"
File PDF document faqs
File PDF document FAQs June 2011 - Alternative (Non-Animal) Methods for Cosmetics Testing
FAQs June 2011
European Commission reports on Progress in the Development of Alternative Methods to Animal Testing for Cosmetics
The report stresses the continued commitment in Europe and worldwide to find alternative approaches.
Meeting of the ECVAM Scientific Advisory Committee
ESAC 35th meeting
JRC-IHCP at the EPAA Annual Conference 2011
"Integrated testing strategies (ITS) and their impact on the 3 Rs (Replace, Reduce, Refine)" - Call for posters: expiry date 21.10.11
'Tools for Innovation', presentation by J. Kreysa to EPAA Annual Conference 2011
Held in Brussels on 09.11.2011
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FAQs Animal Testing 2011
Archived document - Last updated June 2011 - new version (2013) available
Now updated: Agendas of the Meetings, ECVAM scientific committee (ESAC)
Both meetings held in JRC Ispra (Varese) in 2011
SEURAT-1 Research Initiative - Annual Meeting 2011
SEURAT ('Safety Evaluation Ultimately Replacing Animal Testing') pushes for a fundamental change in the way we assess the safety of chemicals
Optimized testing strategies for skin sensitisation - Local Lymph Node Assay (LLNA) and beyond
EPAA workshop
8th World Congress on Alternatives and Animal Use in the Life Sciences
Hosted by the Canadian Council on Animal Care
JRC contribution to EU research initiative on alternatives methods: outcome of the SEURAT-1 2nd Annual Meeting
Lisbon, 8-9th February 2012
EURL ECVAM issues recommendation on three alternative-to-animal testing methods for carcinogenicity
On 14 March 2012 the European Union Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) hosted by the European Commission's Joint Research Centre (JRC) issued a recommendation concerning three in vitro test methods for assessment of the carcinogenic potential of chemical substances. These test methods have the potential to reduce and replace testing on animals for safety assessment in the context of legislation on chemicals and cosmetics.
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EURL ECVAM hosts ICATM meeting
On 22 March, the European Union Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) at the European Commission's Joint Research Centre (JRC) hosted a coordination meeting of the International Cooperation on Alternative Test Methods (ICATM).
‪JRC scientist acts as a guest editor for a special issue of 'Mutation Research' on in vitro cell transformation assays for detection of carcinogens
A comprehensive picture of the development and standardisation status of CTAs (cell transformation assays) co-edited by scientist Raffaella Corvi (European Commission, Joint Research Centre).
JRC scientists develop High-Throughput Liver Toxicity Screening
Scientists from the European Commission Joint Research Centre have designed and demonstrated a high-throughput screening system to categorise chemicals based on their potential to cause liver toxicity. Their approach is based on the quantification of multiple biomarkers of effect that are expressed by HepaRG (liver) cells, treated on a robotic platform and analysed using automated microscopy.
Accelerating the validation of in vitro methods using a high throughput screening platform
EURL ECVAM used an automated robotic in vitro testing platform to generate the data needed for the purposes of validation
JRC scientists use in vitro and in silico tools to describe weak estrogenic activities of Bisphenol A and Bisphenol S
Alternative methods to animal testing bring insights about the structure-activity relationships of these two chemicals
SEURAT-1 Summer School
"Towards the Replacement of In Vivo Repeated Dose Systemic Toxicity Testing": Spread the knowledge from the SEURAT-1 related research areas within and beyond the cluster
EURL ECVAM publishes a search guide on alternatives to animal testing
The European Union Reference Laboratory for alternatives to animal testing provides examples of search procedures and user guidance to facilitate the location of the desired information on 3Rs alternatives (replacement, reduction, refinement of animal use).
File PowerPoint presentation Whelan_presentation_SEURAT1_2011
Evaluation of the neurotoxicity of chemical mixtures
Scientists from the European Commission Joint Research Centre studied the effects of binary mixtures on neuronal networks cultured on multi-electrode array chips. The six chemicals investigated for neurotoxicity were selected according to their mode of action, the possibility for exposure of a consumer and to the amount of data available from the literature concerning their effects on the nervous system.
JRC-IHCP - Poster: 'OECD validation study on the transferability, intra- and inter-laboratory reproducibility of the Zebrafish Embryo Toxicity Test (ZFET)'
Co-authored by JRC-IHCP scientists
JRC contribution: How 21st Century Toxicology can promote 'Green' Chemistry
Research efforts to develop and validate new toxicity-testing and computational tools based on the mode of action of chemi­cals
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8th Annual conference - European Partnership for Alternative Approaches to Animal Testing (EPAA)
Regulators, high-level industry and representatives of the European Commission and other associates to the EPAA are committed to pooling knowledge, research and resources to accelerate the development, validation and acceptance of 3Rs (Replacement, Reduction, Refinement) alternative approaches at an international scale.
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EPAA conference banner
JRC's role in advancing safety assessement science with innovative, non-animal tools
The role of the JRC in international efforts to develop new toxicology tools and thinking has been highlighted by Prof. Maurice Whelan at a European Parliament workshop held in Brussels this week
EURL ECVAM's call for the renewal of the ECVAM Scientific Advisory Committee (ESAC) in 2012
Call for applications for membership of the EURL ECVAM Scientific Advisory Committee (ESAC) - Application deadline postponed: 15th January 2013, midnight
ESAC 2012
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JRC-IHCP team wins first Lush science prize for breakthrough in non-animal chemical safety testing
Awarded to colleagues within the Assay Development and High Throughput Screening Group of the Systems Toxicology Unit for their work on designing a novel in vitro test system for assessing hepatoxicity
JRC-IHCP Lush Science Prize 2012
Lush Science Prize: JRC-IHCP scientists at the award ceremony in London
Interviewed on their research and the EURL ECVAM pioneering work on non-animal chemical safety testing
JRC at the 8th Annual Conference of EPAA (the European Partnership for Alternatives to Animal Testing)
Maurice Whelan (Head of JRC-IHCP Systems Toxicology Unit and EURL ECVAM - the EU Reference Laboratory for Alternatives to Animal Testing) presented EURL ECVAM's contribution to international cooperation in validation of alternative methods in the cosmetics sector
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EPAA logo
Video: JRC-IHCP winners of Lush Science Prize 2012 at the award cerimony in London
Watch Milena Mennecozzi and Brigitte Landesmann receiving the prize on behalf of the Assay Development and High Throughput Screening Group of the JRC-IHCP Systems Toxicology Unit
Alternative methods to animal testing: training course and information exchange with a delegation of the Chinese regulatory authorities (AQSIQ)
Focus on cosmetics regulation and safety assessment
Image JPEG image signature of agreement JRC-IHCP - ECHA
signature of agreement JRC-IHCP - ECHA
ECHA and JRC-IHCP sign a collaboration agreement
Paving the way to the development of common projects included in a cooperation programme which will benefit from the strengths of the two partners.
First ESAC meeting
12-13 April 2010, Ispra (Varese, Italy)
IHCP sessions at AAAS Annual Meeting
The theme of the 2010 AAAS Annual Meeting was "Bridging Science and Society". The JRC organised nine scientific sessions, one of which dedicated to the theme "Protecting the consumer - can 'omics' keep the promise?"
Call for expressions of interest - EURL ECVAM Stakeholder forum (ESTAF)
Open Invitation addressed to stakeholder organisations
JRC nominates the first members of the EU Network of Laboratories for the Validation of Alternative Methods (EU-NETVAL)
An important step to strengthen the EU's capacity to validate new methods that reduce, refine or replace animal testing
Review of available methods for assessing chemical safety promotes alternatives to animal testing
In support of EU legislation on safety of chemicals, the JRC has published a state-of-the art review of test methods and non-testing (computational) approaches that help promote the replacement, reduction, and refinement of animal experiments - known as the 3Rs - in the safety assessment of chemicals.
Launch of the OECD's Adverse Outcome Pathway Knowledge Base
Crowdsourcing information on toxicological mechanisms to further new animal-free approaches to chemical safety assessment
Now online: entirely revised DB service on ALternative Methods
Dissemination of knowledge on advanced and alternative methods - Recent updates
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DB-ALM in Prague
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Image JPEG image Zebra fish (Danio rerio), used in aquatic toxicity testing
Zebra fish (Danio rerio), used in aquatic toxicity testing – courtesy of Prof. T. Braunbeck, University of Heidelberg, Germany
First release of Adverse Outcome Pathway Wiki
A new IT tool in support of OECD's AOP Development programme enters the beta-testing phase
Updated: Free REACH webinars with contributions of EURL ECVAM scientists
Information on alternative methods and testing strategies that could be used to meet REACH requirements
OECD QSAR Toolbox and read-across - First free REACH webinar
Updated information on alternative methods and testing strategies that could be used to meet REACH information requirements on aspects of toxicological hazard of registered chemicals
Skin irritation and corrosion - Second free REACH webinar
Updated information on alternative methods and testing strategies that could be used to meet REACH information requirements on aspects of toxicological hazard of registered chemicals
Serious Eye Damage and Eye Irritation - Third free REACH webinar (one of six)
Updated information on alternative methods and testing strategies that could be used to meet REACH information requirements on aspects of toxicological hazard of registered chemicals
Fast Lane to Chemical Information: JRC launches ChemAgora
JRC portal gives quick overview of where information is available about a chemical across public repositories
40th meeting of EURL ECVAM's Scientific Advisory Committee (ESAC)
Scientific peer review of three validation studies on alternative assays and final advice to EURL ECVAM
EPAA 10th Annual Conference
"How to facilitate the use of alternative methods by regulators?"
Towards improved safety assessment of combined exposure to chemicals
The report "Assessment of Mixtures – Review of Regulatory requirements and Guidance" provides an overview of EU regulations and risk assessment regimes and requirements regarding potential mixtures effects
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File Troff document assessment-mixures-report
JRC launches the EURL ECVAM Genotoxicity & Carcinogenicity Database of Ames positive chemicals
A new JRC resource for predictive toxicology
Skin sensitization - Fourth free REACH seminar (one of six)
Updated information on alternative methods and testing strategies that could be used to meet REACH information requirements on aspects of toxicological hazard of registered chemicals
Alternative approaches for acute systemic toxicity testing: EURL ECVAM releases its strategy
The European Union Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) of the European Commission's Joint Research Centre has just released a strategy on how to replace, reduce and refine the use of animals for acute mammalian systemic toxicity testing
Horizon 2020 Call on New approaches to improve predictive human safety testing
The role of JRC / EURL ECVAM in cooperating with successful consortia
Alternative approaches to mammalian acute systemic toxicity testing - Fifth free REACH seminar (one of six)
Updated information on alternative methods and testing strategies that could be used to meet REACH information requirements on aspects of toxicological hazard of registered chemicals
Webinar: (Zebra)Fish Embryo Acute Toxicity Test to predict short term toxicity to fish (and beyond)
Information on alternative methods and testing strategies that could be used to meet REACH requirements
New EURL ECVAM video explains the validation process of alternative methods (in Italian)
This video presents the European Union Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) and explains the validation process of alternative methods
Image L'iter di convalida di un metodo alternativo (EURL ECVAM)
Questo video presenta il Laboratorio di riferimento dell’Unione Europea per i Metodi Alternativi alla sperimentazione animale (EURL ECVAM)
Image L'iter di convalida di un metodo alternativo (EURL ECVAM)
Nuovo video in Italiano di EURL ECVAM che spiega l'iter di convalida di un metodo alternativo
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