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A research prospectus for developing computational models to predict mitochondrial mediated liver toxicity

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Sep 24, 2012
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A JRC scientist contributed to a commentary that captures the essential features of a proposed research prospectus aimed at guiding the design of projects that intend to develop, validate and apply computational models for use in safety assessment

The prospectus was discussed at an expert workshop organised by the European Partnership for Alternative Approaches to Animal Testing (EPAA) in April this year.
The multi-scale modelling of repeated dose hepatotoxicity induced by chemical interference with mitochondria was chosen as a case study. 

The major take-home message was that computational project design needs to be more innovative and should be driven by modellers and the modelling process itself. The hope is that the ideas conveyed in this commentary will prove useful to the various consortia intending to reply to the "modelling" call for proposals issued during the summer by the European Commission, Directorate-General for Research and Innovation under the 'Health' theme of the EU's Seventh Framework Programme (FP7).

Read more in:

A. R. Leach et al., "Characterising hepatic mitochondrial function as a model for systemic toxicity: A commentary", in Toxicology, 302 (2012) 96– 99
doi:10.1016/j.tox.2012.06.021

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 Image: Mitochondria showing in detail the electron transport chain, complex I-V. (Created with 'Pathway Builder Online' from 'ProteinLounge'. Copyright ProteinLounge 2012).