Toxtree is a flexible and user-friendly open-source application that places chemicals into categories and predicts various kinds of toxic effect by applying decision tree approaches, including the following:
Toxtree was developed by Ideaconsult Ltd (Sofia, Bulgaria) under the terms of a JRC contract. The software is made freely available as a service to scientific researchers and anyone with an interest in the application of computer-based estimation methods in the assessment of chemical toxicity.
Toxtree (Version 2.6.0) (July 2013)
Toxtree 2.6.0 is a standalone software application that can be run on the Microsoft Windows operating system as well as other platforms with the Java 2 Runtime Environment (Standard Edition 1.5 or newer) installed.
Toxtree (Version 1.60) - Download area (July 2009)
The Toxtree software can be downloaded (free of charge) from this website. Toxtree 1.60 is a standalone software application that can be run on the Microsoft Windows operating system as well as other platforms with the Java Runtime Environment (Standard Edition 1.5 or newer) installed.
The setup ("exe") file contains all the required packages for Windows, including the Java(TM) Runtime Environment (JRE 5.0). The archive ("zip") file is an archive of the program without the Windows installer; this can be used to run the program also on a Unix/Linux platform.
In addition to the rulebases already implemented in Toxtree 1.60, the following plug-in was developed by the Istituto Superiore di Sanita' (Rome, Italy) to provide a means of identifying organic functional groups. The ISSFUNC rulebase is a functional groups profiler that implements a set of 204 organic functional groups recognised by the "Checkmol" program, developed by Norbert Haider (University of Vienna, Austria). The jar file should be placed in the "Toxtree\ext\" directory of the Toxtree installation.
Please report any comments, enquiries or bug reports via the dedicated Sourceforge webpage.
Copyright and Disclaimer Notice
Toxtree is open source software; you are authorised to redistribute it and/or modify it under the terms of the GNU General Public License as published by the Free Software Foundation; either version 2 (June 1991) of the License, or any later version. For more details, see the GNU General Public License at http://www.gnu.org/licenses/gpl.txt.
We request that proper credit is given to the copyright and authorship for Toxtree. This includes adding the following copyright notice to the beginning of your source code files, and to any copyright notice that you may distribute with programs based on this work:
Developed by Dr Nina Jeliazkova (Ideaconsult Ltd; contact email@example.com) on behalf of the Joint Research Centre (JRC). Copyright European Union (2005, 2007 & 2008).
The Toxtree software is made available by the JRC as a service to the worldwide scientific and regulatory communities. The JRC and European Communities provide no technical support, warranties or remedies for this software. It does not imply any endorsement or acceptance by the JRC or by the European Commission of the algorithms encoded in the software. The European Commission shall not be liable to the User or any third party for any direct or indirect, special, incidental, punitive, cover or consequential damages, arising out of the use of, or inability to use, Toxtree.