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Presentations: Workshop 'Low Dose Effects and Non-Monotonic Dose Responses for Endocrine Active Chemicals'

Held in Berlin on 11-13 September 2012

Speakers' presentations are now available for this workshop which was sponsored by the National Institute of Environmental Health Sciences (NIEHS)/ NIH, the Oak Foundation, the European Commission, the French Agency for Food, Occupational and Environmental Health (ANSES) , the Federal Environment Agency (UBA) in Germany, the Danish Ministry of the Environment and National Food Institute from Denmark and Charite Medical University, Berlin.

Sixteen presentations are now available for download:

Disclaimer: Please note that contents of the presentations below are the sole responsibility of the speakers and do not necessarily represent the view of the European Commission. 
All the speakers formally authorised publication of their presentation(s) on this web site.

A workshop report is under preparation and will be made available soon.

See also:


 

Day 1: September 11, 2012

 

Opening: Welcome and Meeting Goals

8:30 - 8:45
Welcome
  • Sharon Munn, Joint Research Centre- Institute for Health and Consumer Protection, European Commission, Italy 
  • Jerry Heindel, The National Institute of Environmental Health Sciences (NIEHS), USA
  • Detlev Ganten, Chairman of the Board of the Charité Foundation and President of the World Health Summit, Germany
 
8:45 - 9:00
Opening Comments
  • Linda Birnbaum, Director NIEHS, USA (via video)
  • Elke Anklam, Director, Joint Research Centre-Institute for Health and Consumer Protection, European Commission, Italy
 
9:00 – 9:10
Meeting Goals
  • Sharon Munn, European Commission, Italy
  • Jerry Heindel, NIEHS, USA
 

Session I: Update on Recent Workshops / Activities

9:10 - 9:25
EC Update on EDC Activities
 
9:25 - 9:40
April 2012 Workshop Sponsored by The Pew Charitable Trusts, Nature Journal, and the Institute of Food Technologists
 
9:40 - 10:05
June 2012 Colloquium Sponsored by European Food Safety Authority (EFSA)
 
10:05 - 10:25
Break
 

Session II: Developing a Common Language and Understanding

10:25 - 10:55
How Hormones and Endocrine Disruptors Act
 
10:55 - 11:15
Principles of Pharmacology Related to Low Dose Effects and Non-Monotonic Dose Responses
 
11:15 - 11:45
Practical Principles of Risk Assessment
 
11:45 - 12:15
Facilitated Discussion
  • Discussion Leader: RESOLVE
 
12:15 - 13:15
Lunch (on site)
 

Session III: Occurrence of Low Dose Effects and Non-monotonic Dose Responses for Endocrine Active Chemicals

13:15 - 13:55
State of the Science of Low Dose Effects of Endocrine Active Chemicals
 
13:55 - 14:35
State of the Science of Non-Monotonic Dose Responses in Animal and Human Studies
 
14:35 - 15:00
Break
 
15:00 - 15:30
Computational Modeling of Non-monotonic Dose-Responses: Insights into Minimum Requirements
 
15:30 - 15:45
An Example that Shows the Need to Develop a Strategy for Interpreting Non-Monotonic Responses in Guideline Studies
  • Heather Patisaul, North Carolina State University, USA
 
15:45 - 16:15
Mechanisms for Non-monotonic Dose Responses
 
16:15 - 17:00
Facilitated Discussion
  • Discussion Leader: RESOLVE
 
17:00-17:30
Introduction to Break-out Sessions and Polling
  • Paul De Morgan, RESOLVE, USA
 

Evening Reception

19:00
Henry Ford Bau of the Freie Universität Berlin

 

Day 2: September 12, 2012

 

Session IV: Report on Current Activities

8:30 - 8:45
French Agency for Food, Environmental and Occupational Health (ANSES) Activities Related to Low Dose/Non-monotonic Dose Responses for EDCs
  • Claire Beausoleil, ANSES, France
 
8:45 - 9:10
U01 BPA consortium/Tox 21
 
9:10 - 9:25
Endocrine Society Statement of Principles
 
9:25 - 9:40
US EPA Update on Low Dose-related Activities
 
9:40 - 10:00
Break
 

Session V: Implications of Low Dose and Non-Monotonic Dose Responses for Risk Assessment

10:00 - 10:20
How EFSA Works and Performs Risk Assessment
 
10:20 - 10:50
Impact of Low Dose and Non-Monotonic Dose Responses on Risk Assessment
 
10:50-11:10
OECD Test Guidelines and Endocrine Endpoints
 
11:10 - 11:40
Facilitated Discussion
  • Discussion Leader: RESOLVE
 

Session VI: Day 2 Breakout Session

11:40-12:00
Charge to Breakout Groups
  • Paul De Morgan, RESOLVE
 
12:00-16:00
Breakout Groups (working lunch)
Each breakout group has a RESOLVE facilitator, a chair who will lead discussion, and a rapporteur who will report results
 
16:00-16:30
Break
 
16:30-18:15
Reports from Day 2 Breakout Groups in General Session

Evening Poster Session on Site with Refreshments

18:30-20:00
Location: Südfoyer of the Campus Benjamin Franklin of the Charité

 

Day 3: September 13, 2012

 

Session VII: Day 3 Breakout Session

8:30 - 8:50
Charge to Breakout Groups
  • Paul De Morgan, RESOLVE
 
9:00 - 12:00
Breakout Groups
Each breakout group has a RESOLVE facilitator, a chair who will lead discussion, and a rapporteur who will report results
 
12:00 - 13:00
Lunch
 
13:00 - 15:00
Reports from Day 3 Breakout Groups in General Session
 

Session VII: Wrap-up

15:00 - 15:30
Overall Summary and Path Forward to Continue the Dialogue
  • Sharon Munn, European Commission, Italy
  • Jerry Heindel, NIEHS, USA
 
15:30
Meeting Adjourns

 

Sponsors

NIEHS, EC, Danish Ministry of the Environment, DTU Food, Umwelt Bundes Amt, Anses, Charite