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Young scientists from JRC's EURL ECVAM at the second SEURAT-1 Summer School

News details
Jul 01, 2014

Discussion of recent research activities aimed at replacing in vivo repeated-dose systemic toxicity testing

The second SEURAT-1 Summer School, held in Egmond-aan-Zee (NL) on 8-10 June 2014, was dedicated to young scientists and organised, in collaboration with ESTIV (European Society of Toxicology In Vitro), as a satellite meeting of ESTIV2014 (the 18th International Congress on in vitro Toxicology).

Within the SEURAT-1 cluster, EURL ECVAM (the European Union Reference Laboratory for Alternatives to Animal Testing, hosted by the European Commission Joint Research Centre) is heavily involved in three of the five complementary research projects as well as in the COACH project, which ensures coordination of the entire cluster.


    The objective of the SEURAT-1 Summer School was to spread the knowledge from the SEURAT-1 related research domains w ithin and beyond the cluster. It provided an opportunity for the young researchers to meet their colleagues from the other research groups, present and discuss their work and also to follow mostly practical courses given by eminent experts. This year, the participants had also the unique opportunity to meet the experts attending the ESTIV conference and other satellite meetings and get high visibility for their posters. This training event contributed in creating synergies and strengthening the collaboration within the cluster and with external related  initiatives.

    Several presentations given at the event are now available on the SEURAT-1 web site. 

    Here below some details of the inputs provided by EURL ECVAM's scientists:

    Background information

    The JRC's EURL ECVAM involvement in SEURAT-1 includes research activities in the following areas: development and standardisation of reliable stem cell differentiation protocols; computational prediction tools for determining the fate of a chemical within the body after exposure, and for modelling the reaction of cells to a toxic insult; discovery of new biomarkers at the molecular and cellular level for detecting early toxicological events; high throughput robotic testing to generate high quality datasets using novel in vitro assays; selection of reference chemicals with known toxicological profiles for use in test system development and evaluation; and extension of TTC (Thresholds of Toxicological Concern) safety assessment frameworks to include cosmetic ingredients. The JRC-IHCP is also at the centre of the coordination efforts of the entire cluster, exploiting its considerable experience in the alternatives area to help formulate and implement the SEURAT-1 research strategy, and to facilitate synergies between projects and partners to maximise the impact of collective effort.