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In Vitro Toxicology Systems book shortlisted for a Lush Prize 2015

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Aug 25, 2015
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Co-edited and co-authored by ECVAM scientists, the "In Vitro Toxicology Systems" book has been shortlisted for this year's Lush Prize in the training category. It brings together important issues and considerations needed in order to develop a workable, reliable, integrated testing strategy for the replacement of animals in toxicity testing regimes. The Lush Prize, now in its fourth year, rewards scientists and organisations for their outstanding contributions to replacing animal testing.

This nomination acknowledges the important contribution the volume, published by Human Press (Springer), makes in the dissemination of non-animal methods among scientists, researchers and students.  "In Vitro Toxicology Systems" is edited by Anna Bal-Price (EURL ECVAM and Paul Jennings (Innsbruck Medical University, Austria) and several of the chapters have been written by EURL ECVAM scientists. It includes sections on in vitro testing referring to systemic organ toxicity, neurotoxicity, sensory organs, immunotoxicity and reproductive toxicity. The book also tackles difficult areas of toxicology such as carcinogenicity and nanotoxicology, with additional chapters dedicated to toxicokinetics, metabolism, in silico modelling and in vitro extrapolation. It addresses biological processes such as stress response pathways and mechanistic biomarkers and how these can be uncovered and measured using high content approaches.


This book is of equal benefit to toxicologists and pharmacologists, working in basic research or for regulatory purposes.


The international judges will meet in London in mid-September to decide on the winners for each category.  Winners will receive their award at the ceremony in London on 20 November 2015. The full shortlist is released on the Lush Prize website.


In 2012, the JRC's EURL ECVAM won the LUSH Prize for Science for its ground breaking work on designing a novel high throughput in vitro test system for assessing hepatotoxicity.