Physiologically based toxicokinetic [(PBTK), or alternatively referred to as physiologically based pharmacokinetic (PBPK)] models are quantitative descriptions of absorption, distribution, metabolism, and excretion (ADME) of synthetic or natural chemical substances in humans and other animal species. PBTK models are increasingly being used as an effective tool for designing toxicology experiments and for conducting extrapolations essential for risk assessments (e.g. in pharmaceutical research and drug development, and in health risk assessment for cosmetics or general chemicals).


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  • PBTK
  • Physiology Based ToxicoKinetic Models