The Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) is an interagency committee of the U.S. Government. ICCVAM’s members are scientists representing the heads of 15 U.S. Federal regulatory and research agencies that require, use, generate, or disseminate toxicological information. This information is used to determine the safety or potential adverse health effects of chemicals and products to which workers and consumers may be exposed.

ICCVAM was formed in 1997 by the National Institute of Environmental Health Sciences (NIEHS), one of the National Institutes of Health (NIH). In 2000, the ICCVAM Authorization Act established ICCVAM as a permanent interagency committee of NIEHS under the NTP Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM).

ICCVAM evaluates the scientific validity of new, revised, and alternative test methods, and forwards recommendations on their usefulness to Federal agencies for acceptance decisions.

Source: ICCVAM web site

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