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EURL ECVAM Recommendation on the human Cell Line Activation Test (h-CLAT) for Skin Sensitisation testing

1. EURL ECVAM Recommendation, ESAC Opinion and ESAC WG Report

On 02.03.2015 EURL ECVAM published its Recommendation on the human Cell Line Activation Test (h-CLAT) for Skin Sensitisation testing:

 pdf icon EURL ECVAM Recommendation. Annex 1: ESAC opinion. Annex 2: EURL ECVAM request for advice

pdf icon ESAC Working group Peer Review Consensus Report

2. Relevant validation study reports

pdf icon h-CLAT validation study report

pdf icon h-CLAT validation study report - appendices

pdf icon Post-hoc analysis of the validation study data performed by EURL ECVAM

3. Summary of the changes made in response to public comments received

The recommendation was open for public comments from 28.11.2014 to 31.12.2014. In total three parties submitted comments to EURL ECVAM. In response to these comments two paragraphs in section 4 on the limitations of the method regarding the testing of volatile compounds and metals, were deleted.  In addition further editorial improvements were made throughout the document.