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EURL ECVAM Recommendation on the Direct Peptide Reactivity Assay (DPRA)

For skin sensitisation testing

 

 

1. EURL ECVAM Recommendation, ESAC Opinion and ESAC WG Report

On 12.12.2013 EURL ECVAM published its recommendation on the Direct Peptide Reactivity Assay (DPRA) for skin sensitisation testing:

pdf icon EURL ECVAM Recommendation. Annex 1: ESAC Opinion. Annex 2: EURL ECVAM request for ESAC advice
pdf icon ESAC WG Consensus Report

 

2. Relevant validation study reports

pdf icon DPRA validation study report
pdf icon DPRA validation study report - appendices
pdf icon Addendum - DPRA validation study report

 

3. Summary of the changes made in response to public comments received 
 

The recommendation was open for public comments from 1.08.2013 to 13.09.2013. One comment was received which led to the following change in the document, together with further editorial improvements:

In the context of discussing the likely need to combine information generated by different testing and non-testing methods to conclude on the sensitisation hazard potential of chemicals, a sentence was added stating that it should not be ruled out a priori that skin sensitisation testing may, in the future, be addressed by one single method only.