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EURL ECVAM Recommendation on the Cell Transformation Assay based on the Bhas 42 cell line

1. EURL ECVAM Recommendation, ESAC Opinion and ESAC WG Report

On 17.12.2013 EURL ECVAM published its recommendation on the Bhas 42 cell line-based Cell Transformation Assay (CTA) for carcinogenicity testing:

pdf icon EURL ECVAM Recommendation. Annex 1: ESAC Opinion. Annex 2: EURL ECVAM request for ESAC advice
pdf icon ESAC WG Consensus Report


2. Relevant validation study reports

pdf icon Bhas CTA validation study report

3. Summary of the changes made in response to public comments received

The recommendation was open for public comments from 01.08.2013 to 13.09.2013. One comment was received which led to the following change in the document, together with further editorial improvements:

A sentence was added informing that the use of genetically modified cell lines might be subject to country-specific authorisation provisions.