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EURL ECVAM Recommendations

The aim of an EURL ECVAM Recommendation is to provide EURL ECVAM views on the validity of the test method in question, to advice on possible regulatory applicability, limitations and proper scientific use of the test methods, and to suggest possible follow-up activities in view of addressing knowledge gaps.

During the development of its Recommendation EURL ECVAM consults with its consultation body for Preliminary Assessment of Regulatory Relevance (PARERE) and its EURL ECVAM Stakeholder Forum (ESTAF). Moreover, EURL ECVAM consults with other Commission services and its international validation partner organisations of the International Collaboration on Alternative Test Methods (ICATM). Moreover, before finalising its recommendations, EURL ECVAM invites comments from the general public and, if applicable, from the test method submitter.

 

Health / environmental endpointRecommendations
Skin Sensitisationhuman Cell Line Activation Test (h-CLAT) for Skin Sensitisation testing02.03.2015
Acute aquatic (fish) toxicity Zebrafish Embryo Acute Toxicity Test Method (ZFET) for Acute Aquatic Toxicity Testing 25.07.2014
Skin Sensitisation  KeratinoSens™ assay for Skin Sensitisation testing 17.02.2014 
Carcinogenicity Cell Transformation Assay for carcinogenicity testing based on the Bhas 42 cell line 17.12.2013
Skin Sensitisation Direct Peptide Reactivity Assay (DPRA) 12.12.2013
Acute Oral Toxicity 3T3 NRU Assay for Supporting the Identification of Substances Not Requiring Classification for Acute Oral Toxicity 02.05.2013
Carcinogenicity Three Cell Transformation Assays for in vitro Carcinogenicity Testing 14.03.2012