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EURL-ECVAM: Launch of two ESAC peer-reviews in August 2012

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Sep 07, 2012
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Performance Standards for Cytosensor Microphysiomer test method; validation study on a cell transformation assay for carcinogenicity testing based on the Bhas42 cell line

Two peer reviews were launched by EURL ECVAM (the European Union Reference Laboratory for Alternatives to Animal Testing) in August 2012.

  • On 7 August 2012 EURL ECVAM launched the peer-review of the Performance Standards (PS) for the Cytosensor Microphysiometer (CM) test method.
    The CM test method is a cell function-based in vitro assay. It is based on a measurement of cytotoxicity, considered a key mechanism of eye irritation and corrosion. It aims to identify ocular corrosives and severe eye irritants as well as non-irritants for certain chemical classes and is considered an alternative to the animal based Draize rabbit eye irritation test. 
    The Performance Standards were elaborated by EURL ECVAM and aim at setting standards for similar methods that will be developed in the future. After successful assessment by EURL ECVAM's independent Scientific Advisory Committee (ESAC), the  Performance Standards will be proposed to the OECD for inclusion into the new draft Test Guideline on the CM test method.
  • On 23 August 2012 EURL ECVAM launched the peer-review of the validation study on a cell transformation assay (CTA) for carcinogenicity testing based on the Bhas42 cell line.
    The study was coordinated by the Japanese Center for the Validation of Alternative Methods (JaCVAM) and is reviewed by the EURL ECVAM Scientific Advisory Committee (ESAC). 
    A dedicated ESAC working group has been set up, which is now going to start the assessment of the reliability and relevance of the Bhas42 CTA and to convene its first meeting on 1 October 2012.