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Our scientists show you what they are doing to advance safety assessment of chemicals without relying on animal testingdefault frame updated video

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The European Union Reference Laboratory for alternatives to animal testing (EURL-ECVAM) has been formally established in 2011, due to the increasing need for new methods to be developed and proposed for validation in the European Union. EURL ECVAM is hosted by the Joint Research Centre located in Ispra, Italy.

EURL ECVAM has a long tradition in the validation of methods which reduce, refine or replace the use of animals for safety testing and efficacy/potency testing of chemicals, biologicals and vaccines. Research laboratories are able to submit to EURL ECVAM for scientific validation the alternative methods to animal testing that they have developed.

EURL ECVAM also promotes the development and dissemination of alternative methods and approaches, their apEURL-ECVAMplication in industry and their acceptance by regulators.

The European Commission's involvement in activities targeted to the validation of alternative approaches to animal testing started in 1991, with the launch of ECVAM (the European Centre for the Validation of Alternative Methods), hosted by the Joint Research Centre. As from 2011, ECVAM's tasks are assigned to EURL ECVAM.Cell culture under sterile conditions-2

The menu on the left hand side of the page helps you browse through the main content sections of the EURL ECVAM web site.

To contact EURL ECVAM, please use this interactive form.

Photo: Cell culture under sterile conditions in the EURL ECVAM microbiology laboratory. Copyright EU 2012.

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highlights

A 21st-century roadmap for biomedical research A 21st-century roadmap for biomedical research - Feb 15, 2017 JRC scientist contributes to the definition of a 21st-century roadmap for biomedical research which proposes the use of human-specific models and innovative in vitro technologies instead of animals.
JRC hosts the VAC2VAC workshop on validation of non-animal methods for quality control of vaccines JRC hosts the VAC2VAC workshop on validation of non-animal methods for quality control of vaccines - Feb 10, 2017 The JRC's EU Reference Laboratory for alternatives to animal testing (EURL ECVAM) organised this workshop with VAC2VAC partners from the 30th January to the 1st February 2017 to discuss ways of improving multi-centre validation studies and making use of the data generated for product-specific validation purposes.
How Adverse Outcome Pathways can support computational approaches to predictive toxicology How Adverse Outcome Pathways can support computational approaches to predictive toxicology - Feb 03, 2017 Scientists from the JRC and eleven collaborating organisations from the EU, Canada and the USA have shared their collective insights on how adverse outcome pathways (AOP) can aid the development and use of computational prediction models for regulatory toxicology.
JRC continues its Good Cell Culture Practice efforts JRC continues its Good Cell Culture Practice efforts - Jan 30, 2017 JRC scientists - in close collaboration with international organisations – revised the first guidance on Good Cell Culture Practice (GCCP) by expanding it to aspects of quality assurance for in vitro cell culture focusing on the increasingly diverse cell types and culture formats used in research and elsewhere.
Criteria for selection of reference chemicals for the evaluation of alternative methods to assess developmental neurotoxicity Criteria for selection of reference chemicals for the evaluation of alternative methods to assess developmental neurotoxicity - Jan 25, 2017 In collaboration with international organisations, a JRC scientist defined criteria for the selection of positive/negative control samples to assess developmental neurotoxicity hazard posed by environmental and industrial chemicals.
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events

JRC Summer School on Alternative Approaches for Risk assessment  - THE PATH FROM SCIENCE TO PROTECTION OF HUMAN HEALTH AND THE ENVIRONMENT JRC Summer School on Alternative Approaches for Risk assessment - THE PATH FROM SCIENCE TO PROTECTION OF HUMAN HEALTH AND THE ENVIRONMENT - May 16, 2017 - May 19, 2017 The JRC's Chemical Safety and Alternative Methods Unit, which incorporates the EU Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM), is organising a JRC Summer School from the 16-19 May 2017, at the JRC Ispra site, on the topic of "Alternative Approaches for Risk Assessment". The overall aim is to provide comprehensive training on state-of-the-art alternative (non-animal) approaches to predictive toxicology and to promote their use within modern chemical risk assessment practice.
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calls

Call for experts to serve on EURL ECVAM's Scientific Advisory Committee (ESAC) Call for experts to serve on EURL ECVAM's Scientific Advisory Committee (ESAC) The European Union Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) is renewing membership of its EURL ECVAM Scientific Advisory Committee (ESAC). Interested scientific experts who satisfy the eligibility criteria and who possess the relevant competences are invited to apply (Deadline 31st January 2017).
EURL ECVAM extends the EU Network of Laboratories for the Validation of Alternative Methods (EU-NETVAL) EURL ECVAM extends the EU Network of Laboratories for the Validation of Alternative Methods (EU-NETVAL) Supporting the validation and implementation of in vitro methods for regulatory use
Horizon 2020 Call on New approaches to improve predictive human safety testing Horizon 2020 Call on New approaches to improve predictive human safety testing The role of JRC / EURL ECVAM in cooperating with successful consortia
Call for expressions of interest - EURL ECVAM Stakeholder forum (ESTAF) Open Invitation addressed to stakeholder organisations
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multimedia

Toxicological Testing of Chemicals & EURL ECVAM Toxicological Testing of Chemicals & EURL ECVAM Faces of Science - showcasing the human face of the scientific advice supporting EU policy. Maurice Whelan at the Joint Research Centre, the European Commission's in-house science service, presents the Toxicological Testing of Chemicals and EURL ECVAM
New EURL ECVAM video explains the validation process of alternative methods (in Italian) New EURL ECVAM video explains the validation process of alternative methods (in Italian) This video presents the European Union Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) and explains the validation process of alternative methods