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Chemical safety assessment: experts’ workshop presents new scenarios for repeated dose target organ toxicity

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May 14, 2014

Outcome of the SEURAT-1 Read-Across Workshop held in Ispra on 29-30 April 2014

In April 2013 the Joint Research Centre’s Institute for Health and Consumer Protection and the SEURAT-1 Safety Assessment Working Group jointly organised a workshop on read-across to be applied in chemical safety assessment.

SEURAT-1 is a 5 year Research Initiative started in 2011 aiming on the replacement of repeated dose systemic toxicity testing in vivo, used for the assessment of human safety (Safety Evaluation Ultimately Replacing Animal Testing). The JRC’s IHCP supports the activities of the SEURAT-1 Safety Assessment Working Group and contributes to the ultimate Proof-of-Concept of the SEURAT-1 research initiative.

Experts from a range of institutions and agencies (including the OECD, US EPA, Scientific Committee on Consumer Safety (SCCS), European Food Safety Authority and ECHA), academia and industry attended the workshop in Ispra (Italy). The idea was to collect the best available advice on read across from different expertise to inform the case study taken on board as a Proof-of-Concept of the SEURAT-1 strategy and to select suitable chemical categories.

The experts agreed on four read across scenarios for repeated dose target organ toxicity and on suitable reference chemicals for each scenario. It was thoroughly discussed how chemical and biological similarities could be used to complement each other, biological similarities primarily being based on information achieved from new in vitro approaches, either from the SEURAT-1 methods or EPA ToxCast.

The recommendations on how to carry out the read across case study will be further discussed within the SEURAT-1 consortia, where also the different case study scenarios will be completed as a first step with already available data and a second step with complementary new data. When the read across case study is finalised, towards the end of 2015, it will be evaluated whether it fulfils the requirements for regulatory acceptance for chemical safety assessment.

See also: SEURAT-1 web site