Call for comments on two EURL ECVAM Recommendations
|Aug 07, 2013|
The European Union Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) is inviting public comments on its latest Recommendations concerning two alternative test methods. Deadline for comments: 13th September 2013
Recommendations concerned are:
- Direct Peptide Reactivity Assay (DPRA) for contributing to the assessment of chemicals concerning their potential to cause skin sensitisation and
- Cell Transformation Assay (CTA) based on the Bhas 42 cell line aiming at predicting the potential of chemicals to cause cancer.
Both methods are not considered to be standalone tests for these health effects but are envisaged to be used within integrated approaches for safety assessment.
The aim of a EURL ECVAM Recommendation is to provide EURL ECVAM views on the validity of a test method and to advise on possible regulatory applicability, limitations and proper scientific use. A Recommendation also suggests possible follow-up activities in view of addressing knowledge gaps and broadening a method's applicability.
The Recommendations are based on opinions of the EURL ECVAM Scientific Advisory Committee (ESAC) which peer-reviewed the validation studies. The ESAC opinions are annexed to the Recommendation documents. Prior to this public commenting phase, EURL ECVAM consulted with its advisory body for Preliminary Assessment of Regulatory Relevance (PARERE), the EURL ECVAM Stakeholder Forum (ESTAF) and its international validation partner organisations within the International Cooperation on Alternative Test Methods (ICATM).
The relevant documentation and details for submission of comments are available at the following link: EURL ECVAM Recommendations - Public Comments