Statements & Opinions

by ECVAM Scientitic Advisory Committee (ESAC)

 

List of all ESAC Statements on Alternative Methods

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ESAC Statements on Alternative Methods pdf icon

ESAC Statements - Chemicals, Cosmetics and Pesticides

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2009
ESAC statement on the scientific validity of two in vitro eye irritation test methods pdf icon
ESAC statement on the use of existing LVET data for classification and labelling purposes pdf icon
ESAC statement on reference chemicals for validating reconstructed human epidermis for skin corrosion testing pdf icon
Updated ESAC statement on the performance under UN GHS of skin irritation tests and the associated ECVAM reference chemicals pdf icon
ESAC statement on the updated ECVAM Performance Standards for in vitro skin irritation testing pdf icon
ESAC statement on the scientific validity of an in-vitro test method for skin corrosivity testing pdf icon
2008
Statement on the Performance Standards (PSs) for the Local Lymph Node Assay (LLNA) pdf icon
Statement on the Scientific Validity of In Vitro Tests for Skin Irritation Testing pdf icon
Statement on the use of FCS and other animal-derived supplements pdf icon
2007
Statement on the OECD adopted Test Guidelines for Acute Oral Toxicity Testing pdf icon
Statement on the Reduced Local Lymph Node Assay (rLLNA) pdf icon
Statement on the Validity of In Vitro Tests for Skin Irritation pdf icon
Statement on the Conclusions of the ICCVAM Retrospective Study on Organotypic In Vitro Assays as Screening Tests to Identify Potential Ocular Corrosives and Severe Irritants. pdf icon
Interim Statement on the RETox Assay for Embryotoxicity Testing. pdf icon
2006
Statement on Dog Toxicity Studies pdf icon
Statement on the Application of the SkinethicTM Human Skin Model. pdf icon
Statement on the Scientific Validity of the In Vitro Micronucleus Test. pdf icon
Acute Aquatic Toxicity Testing pdf icon
Statement on the Application of the CFU-GM Assay for Predicting Acute Neutropenia in Humans pdf icon
2001
In Vitro Embryotoxicity Tests employing micromass culture, rat embryo cultures, and embryonic stem cells pdf icon
2000
CORROSITEX Skin Corrosivity Test pdf icon
EpiDermTM skin corrosivity test pdf icon
Local lymph node assay for skin sensitisation pdf icon
1998
Application of the 3T3 Neutral Red Uptake (NRU) phototoxicity test to UV filter chemicals pdf icon
Rat Transcutaneous Electrical Resistance (TER) skin corrosivity test pdf icon
EpiSkinTM skin corrosivity test pdf icon
1997
3T3 Neutral Red Uptake (NRU) phototoxicity test pdf icon

ESAC Statements - Biologicals / Pharmaceuticals

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2006
5 In Vitro Pyrogen Tests pdf icon
The CFU-GM Assay for Predicting Acute Neutropenia in Humans pdf icon
2002
The relevance of the target-animal safety test for batch safety testing of vaccines for veterinary use pdf icon
The batch potency testing of erythropoietin concentrated solution pdf icon
The ELISA test for batch potency testing of erysipelas vaccines pdf icon
2000
ELISA test for potency testing of tetanus vaccines for human use pdf icon
Toxin Binding Inhibition (ToBI) test for potency testing of tetanus vaccines for human use pdf icon
1998
In vitro production of monoclonal antibodies pdf icon

Statements by Non-Commission Members of the ESAC

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2007
ESAC Position on ECVAM Funding pdf icon
2006
Statement on ECVAM Funding pdf icon
Statement on Directive 86/609/EEC Article 23 on opportunities for training and development of science in validation of the 3Rs. pdf icon
2005
Intelligent Testing Strategies Paper pdf icon
Validation of Proprietary Methods pdf icon
Status of Validation of the Uterotrophic Assay pdf icon
2001
Proposals for a 7th Amendment to Directive 76/768/EEC pdf icon
Funding of alternatives in the 6th Framework Programme pdf icon
2000
Deletion of the LD50 test pdf icon
Use of Animals in Research pdf icon
1999
Funding of alternatives in the 5th Framework Programme pdf icon