Tasks area publications 2004-2005

  • Barriers, Nephrotoxicity and Chronic Testing
  • Biologicals
  • Biostatistics
  • Computational Toxicology
  • Culture Methodologies
  • Ecotoxicology
  • Local Toxicity
  • Metabolism
  • Reproductive Toxicity
  • Scientific Information Service (SIS)

Barriers, Nephrotoxicity and Chronic Testing

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Gennari, A., Pazos, P., Boveri, M., Maurici, D., Casado, J., Prieto, P., Corsini, E. and Callaghan, R. (2004). New Insights into the Mechanisms Involved in Renal Proximal Tubular Damage Included in vitro by Ochratoxin A. Journal of Biochemical and Molecular Toxicology.  
Prieto, P., Boveri, M.,Coecke, S., Price, A., Blauuboer, B.J., De Boer, A.G., Cecchelli, R., Clemedson, C., Forsby, A., Galla, H., Garberg, P., Greenwood, J. and Tahti,H. (2004). Blood-Brain Barrier in vitro Models and their Application in Toxicology. ATLA,  


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Hoffmann, S., Luederitz-Puechel, U., Montag-Lessing, T., Hartung, T. (2005). Optimisation of pyrogen testing in parenterals according to different pharmacopoeias by probabilistic modeling. Journal of Endotoxin Research,11(1), 26-31.  
Hoffmann, S. et al. (2005). International validation of novel pyrogen tests based on human monocytoid cells. Journal of Immunological Methods298(1-2), 161-173.  


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Hoffmann, S. and Hartung, T. (2005). Diagnosis: Toxic! -Trying to apply approaches of clinical diagnostics and prevalence in toxicology considerations. Toxicological Sciences85, 422-428.  

Computational Toxicology

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Lessigiarska, I., Cronin, M.T.D., Worth, A.P., Dearden, J.C. and Netzeva, T.I. (2004). QSARs for Toxicity to the Bacterium Sinorhizobium meliloti. SAR and QSAR in Environmental Research, 15, 169-190.  
Worth, A.P. (2004). The Tiered Approach to Toxicity Assessment Based on the Integrated Use of Alternative (non-Animal) Tests. In Monogr.: Predicting Chemical Toxicity and Fate, 389-410. Cronin, M.T.D. and Livingstone, D. (Eds.), CCR Press, Boca Raton, FL (USA).  
Worth, A.P. and Balls, M. (2004). The Principles of Validation and the ECVAM Validation Process. In: Proceedings of the Fourth World Congress on Alternatives and Animal Use in the Life Sciences. 11-15 August 2002, New Orleans, USA. ATLA, 32, Suppl. 1B, 623-629. pdf icon
Worth, A.P. and Cronin, M.T.D. (2004). Report of the Workshop on the Validation of QSARs and Other Computional Prediction Models. In: Proceedings of the Fourth World Congress on Alternatives and Animal Use in the Life Sciences. 11-15 August 2002, New Orleans, USA. ATLA, 32, Suppl. 1B, 703-706. pdf icon

Culture Methodologies

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van der Valk, J., Mellor, D., Brands, R., Fischer, R., Gruber, F., Gstraunthaler, G., Hellebrekers, L., Hyllner, J., Jonker, F., Prieto Peraita, P., Thalen, M. and Baumans, V. (2004). The Human Collection of Fetal Bovine Serum and Possibilities for Serum-Free Cell and Tissue Culture. Toxicology in vitro, 18,1, 1-12.  


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Jeram S., Riego Sintes J.M., Halder M., Baraiber Fentanes J., Sokull-Kluttgen B., Hutchinson T.H., (2005). A strategy to reduce the use of fish in acute ecotoxicity testing of new chemical substances notified in the European Union. Regulatory Toxicology and Pharmacology 42, 218-224.  

Local Toxicity

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Hoffmann, S., Cole, T., Hartung, T. (2005). Skin irritation: Prevalence, variability and regulatory classification of existing in vivo data from industrial chemicals. Regulatory Toxicology and Pharmacology41(3), 159-66.  


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Bogni, A., Monshouwer, M., Moscone, A., Doehmer, J., Hidestrand, M., Ingelman-Sundberg, M., Hartung, T. and Coecke, S. (2004). The Relative Activities of Polymorphic CYP2D6 Allele are Substrate Dependent.Drug Metabolism and Disposition  

Reproductive Toxicity

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Bremer, S. and Hartung, T. (2004). The Use of Embryonic Stem Cells for the Regulatory Development Toxicity Testing in vitro. The Current Status of Test Development. Current Pharmaceutical Design  
Genschow, E., Spielmann, H., Scholz, G., Pohl, I., Seiler, A., Clemann, N., Bremer, S. and Becker, K. (2004). Validation of the Embryonic Stem Cell Test (EST) in the International ECVAM Validation Study of three in vitro Embryotoxicity Tests. ATLA  
Pelizzer, C., Adler, S., Corvi, R., Hartung, T. and Bremer, S. (2004). Monitoring of Teratogenic Effects in vitro by Analysing a Selected Gene Expression Pattern. Toxicology in vitro, 18, 325-335.  

Scientific Information Service (SIS)

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Roi, A.J. and Burke, A. (2004). The ECVAM Scientific Information Service (SIS). In: Proceedings of the Fourth World Congress on Alternatives and Animal Use in the Life Sciences. 11-15 August 2002, New Orleans, USA. ATLA, 32, Suppl. 1B, 569-572. pdf icon
Grune, B., Fallon, M., Howard, C., Hudson, V., Kulpa-Eddy, J.A., Larson, J., Leary, S., Roi, A., van der Valk, J., Wood, M., Doerendahl, A., Koehler-Hahn, D., Box, R. and Spielmann, H. (2004). Report and Recommendations of the International Workshop - Retrieval Approaches for Information on Alternative Methods to Animal Experiments, held in Berlin in 2003 at ZEBET. ALTEX, 21, 115-127. pdf icon