Tasks area publications 2000-2001


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Council of Europe (2000). Collaborative study for the validation of serological methods for the potency testing of tetanus toxoid vaccines for human use. Part 1. Pharmeuropa Special issue, BIO 2000-1, 83-124.  
Cussler K., Morton D.B., and Hendriksen, C.F.M. (2000). Possibilities for the use of humane endpoints in vaccine potency tests. In M. Balls, A-M. van Zeller and M.E. Halder (eds). Progress in the Reduction, Refinement and Replacement of Animal Experimentation, 915-927. Amsterdam: Elsevier Science B.V.  
Cussler, K., van der Kamp, M.D.O., and P￶ssnecker, A. (2000). Evaluation of the relevance of the target animal safety test. In M. Balls, A-M. van Zeller and M.E. Halder (eds), Progress in the Reduction, Refinement and Replacement of Animal Experimentation, 809-816. Amsterdam: Elsevier Science B.V.  
HELP (2000). Video: Humane endpoints replace lethal parameters in batch potency tests of rabies vaccines.  

Barriers, Nephrotoxicity and Chronic Testing
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Kusuhara H., Sugiyama Y. (2001). Efflux transport systems for drugs at the blood-brain barrier and blood-fluid-cerebrospinal fluid barrier (part 1). Drug Discovery Today 6: 150-156.  

Computer Modelling and Integrated Testing
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Worth, A.P. & Cronin, M.T.D. (2001). The use of bootstrap resampling to assess the uncertainty of Cooper statistics. Alternatives to Laboratory Animals 29, in press.  
Worth, A.P. & Cronin, M.T.D. (2000). Embedded cluster modelling: a novel QSAR method for generating elliptic models of biological activity. In: Progress in the Reduction, Refinement and Replacement of Animal Experimentation (eds. M. Balls, A-M. van Zeller & M.E. Halder). pp. 479-491. Elsevier Science, Amsterdam.  
Worth, A.P. & Cronin, M.T.D. (2000). Structure-permeability relationships for transcorneal penetration. Alternatives to Laboratory Animals 28, 403-413.  

Embryo and Cardiotoxicity
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Bremer S., Worth A., Paparella M., Bigot K., Kolossov E., Fleischmann B., Hescheler J. and Balls M., (2001). Establishment of an in vitro reporter gene assay for developmental cardiac toxicity. Toxicology in vitro 15, 215-223  
Spielmann H, Genschow E, Scholz G, Brown NA, Piersma AH, Brady M, Clemann N, Huuskonen H, Paillard F, Bremer S, Becker K. (2001). Preliminary results of the ECVAM validation study on three in vitro embryotoxicity tests. ATLA 29, 301-303.  
Coecke S., Catalani P., Bull S., Langezaal I., Bogni A., Bremer S. and Balls M. (2000). The integrated use of a genetically engineered cell line panel harbouring drug metabolising enzymes to detect metabolism-related problem compounds. Progress in the Reduction, Refinement and Replacement of Animal Experimentation, 147-157  
Genschow E., Scholz G., Brown N., Piersma A., Brady M., Clemann N., Huuskonen H., Paillard F., Bremer S., Becker K. and Spielmann H. (2000). Development of prediction models for three in vitro embryotoxicity tests. In vitro and Molecular Toxicology 13, 65  
Vogel R., Domke A., Tenschert B. and Bremer S. (2000). In vitro germ cell models for the detection of fertility impairment. Andrologia 32, 219-24  

Eye Irritation
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Zuang, V. (2001) The Neutral Red Release assay: A review. ATLA 29, 1-25.  

GLP, GCCP and In Vitro Toxicity
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Hartung, T., Gstraunthaler, G., Coecke, S., Lewis, D., Blanck, O. and Balls, M. (2001). Good Cell Culture Practice (GCCP) - eine Initiative zur Standardisierung und Qualita Tssicherung von in vitro Arbeiten Die Etablierung einer ECVAM Task Force on GCCP.Altex 18, 75-78.  
Coecke, S., Cooper-Hannan, R. & Harbell, J. (2000) Good Laboratory Practice and in vitro toxicology. In: Progress in the Reduction, Refinement, and Replacement of Animal Experimentation (eds. M. Balls, A.-M van Zeller and M.E. Halder), pp. 1651-1653. Elsevier Science B.V., U.K.  

Haematotoxicity and Anti-cancer Drugs
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Malerba, I., Castoldi, A.F., Parent-Massin D. and Gribaldo, L. (2001). In vitro myelotoxicity of Propanil and 3,4-Dichloroaniline on murine and human CFU-E/BFU-E progenitors., accepted for publication on Toxicological Sciences.  
Pessina, A., Albella, B., Bueren, J., Brantom, P., Casati, S., Gribaldo, L., Croera, C., Gagliardi, G., Foti, P., Parchment, R., Parent-Massin, D., Sibiril, Y., Schoeters, G. and Van Den Heuvel, R (2001). Prevalidation of a model for predicting acute neutropenia by Colony Forming Unit-Granulocyte/Macrophage (CFU-GM) assay, Toxicology in Vitro 15, 729-740.  
Gribaldo, L. MD, Malerba, I., Collotta, A., Casati, S., Pessina, A. (2000). Inhibition of CFU-E/BFU-E by 3'-azido-3'-deoxythymidine, chlorpropamide and protoporphirin IX zinc (II): a comparison between direct exposure of progenitor cells and long-term exposure of bone marrow cultures. Toxicological Sciences 58, 96-101.  

Human Studies
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Zuang, V., Archer, G., Rona, C., Vignini, M., Mosca, M. & Berardesca, E. (2000) Predicting visual assessment of allergic patch test reactions by non-invasive measurements. Skin Pharmacology and Applied Skin Physiology 13, 39-51.  
Zuang, V., Rona, C., Archer, G. & Berardesca, E. (2000) Detection of skin irritation potential of cosmetics by non-invasive measurements. Skin Parmacology and Applied Skin Pysiology 13, 358-371.  

Immunotoxicity and Pyrogenicity
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Langezaal, I., Coecke, S. and Hartung, T.(2001). Whole blood cytokine response as a measure of immunotoxicity. Toxicology in Vitro 15, 313-318.  
Sladowski, D., Kinsner, A., Langezaal, I., Kay, S. and Coecke, S. (2001) Activation of the complement system as an indicator of pyrogenic reaction to lipopolysaccharide (LPS). Toxicology in Vitro 15, 339-342.  

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Bull, S., Langezaal, I., Clothier, R. & Coecke, S. (2001) A genetically engineered cell-based system for detecting metabolism-mediated toxicity. ATLA 29, 703-716.  
Coecke, S., Bogni, A., Langezaal, I., Worth, A., Hartung, T. and Monshouwer, M. (2001). The use of genetically engineered cells for assessing CYP2D6-related polymorphic effects, Toxicology in Vitro 15, 553-556.  
LeCluyse, EL. (2001) Human hepatocyte culture systems for the in vitro evaluation of cytochrome P450 expression and regulation. European Journal of Pharmaceutical Sciences 13, 343-368.  
Coecke , S., Catalani, P., Bull, S., Langezaal, I., Bogni, A., Bremer, S. & Balls, M. (2000) The integrated use of a genetically engineered cell line panel harbouring drug metabolising enzymes to detect metabolism-related problem compounds. In: Progress in the Reduction, Refinement, and Replacement of Animal Experimentation (eds. M. Balls, A.-M. van Zeller and M.E. Halder), pp. 147-157. Elsevier Science B.V., U.K.  

Scientific Information Service (SIS)
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J-Roi, A., Libowitz, L., Grune, B. and Kreger, M.. Alternative method databases - Specialised information sources on alternatives in support to scientists and authorities responsible for granting project licences (2000). Proceedings of the 3rd World Congress on Alternatives and Animal Use in the Life Sciences, 29 August-2 September 1999, Bologna (I): "Progress in reduction, refinement and replacement of animal experimentation" edit. by M.Balls et.al. Developments In Animal and Veterinary Sciences 31, 1731-1736.  

Skin Corrosivity
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Liebsch, M., Traue, D., Barrabas, C., Spielmann, H., Uphill, P., Wilksins, S., McPherson, J.P., Wiemann, C., Kaufmann, Remmele, M. & Holzhtter, H-G. (2000). The ECVAM prevalidation study on the use of EpiDermTM for skin corrosivity testing. ATLA 28, 371-401.  

Skin Irritation
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Fentem, J.H., Briggs, D., Chesn←, C., Elliott, G.R., Harbell, J.W., Heylings, J.R., Portes, P., Roguet, R., van de Sandt, J.J.M. & Botham, P.A. (2001) A prevalidation study on in vitro tests for acute skin irritation: results and evaluation by the Management Team.Toxicology in Vitro 15, 57-93.