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Our scientists show you what they are doing to advance safety assessment of chemicals without relying on animal testingdefault frame updated video

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The European Union Reference Laboratory for alternatives to animal testing (EURL-ECVAM) has been formally established in 2011, due to the increasing need for new methods to be developed and proposed for validation in the European Union. EURL ECVAM is hosted by the Joint Research Centre located in Ispra, Italy.

EURL ECVAM has a long tradition in the validation of methods which reduce, refine or replace the use of animals for safety testing and efficacy/potency testing of chemicals, biologicals and vaccines. Research laboratories are able to submit to EURL ECVAM for scientific validation the alternative methods to animal testing that they have developed.

EURL ECVAM also promotes the development and dissemination of alternative methods and approaches, their apEURL-ECVAMplication in industry and their acceptance by regulators.

The European Commission's involvement in activities targeted to the validation of alternative approaches to animal testing started in 1991, with the launch of ECVAM (the European Centre for the Validation of Alternative Methods), hosted by the Joint Research Centre. As from 2011, ECVAM's tasks are assigned to EURL ECVAM.Cell culture under sterile conditions-2

The menu on the left hand side of the page helps you browse through the main content sections of the EURL ECVAM web site.

To contact EURL ECVAM, please use this interactive form.

Photo: Cell culture under sterile conditions in the EURL ECVAM microbiology laboratory. Copyright EU 2012.

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highlights

JRC hosts a meeting to strengthen its collaboration with the European Food Safety Authority (EFSA) JRC hosts a meeting to strengthen its collaboration with the European Food Safety Authority (EFSA) - Apr 10, 2017 On 5th April JRC-Ispra hosted a delegation from EFSA to discuss specific topics of common interest in the area of risk assessment related to chemicals.
Understanding nanomaterial toxicity by leveraging mechanistic information on chemicals Understanding nanomaterial toxicity by leveraging mechanistic information on chemicals - Apr 05, 2017 JRC scientists carried out a study illustrating how the mechanisms of nanomaterial toxicity can be better understood by exploiting the broader body of mechanistic information on chemicals in general.
The pathway from liver injury to liver fibrosis The pathway from liver injury to liver fibrosis - Apr 04, 2017 JRC scientists have used an Adverse Outcome Pathway approach to explain how some chemicals can potentially cause liver fibrosis in humans in order to support the development of non-animal approaches to chemical safety assessment.
EURL ECVAM is inviting public comments on its draft Recommendation on the use of non-animal approaches for skin sensitisation testing - Mar 31, 2017 The European Union Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) is inviting public comments on its latest draft Recommendation concerning the use of non-animal approaches for skin sensitisation testing.
JRC meets with OECD experts to define good practices for in vitro methods JRC meets with OECD experts to define good practices for in vitro methods - Mar 24, 2017 On the 23rd and 24th of March the JRC's EU Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) hosted a meeting with OECD experts to discuss the draft of a guidance document on Good In Vitro Method Practice (GIVIMP). This GIVIMP document would serve as a technical guidance on good scientific and quality practices to support the regulatory human safety assessment of chemicals using in vitro methods.
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events

JRC Summer School on Alternative Approaches for Risk assessment  - THE PATH FROM SCIENCE TO PROTECTION OF HUMAN HEALTH AND THE ENVIRONMENT JRC Summer School on Alternative Approaches for Risk assessment - THE PATH FROM SCIENCE TO PROTECTION OF HUMAN HEALTH AND THE ENVIRONMENT - May 16, 2017 - May 19, 2017 The JRC's Chemical Safety and Alternative Methods Unit, which incorporates the EU Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM), is organising a JRC Summer School from the 16-19 May 2017, at the JRC Ispra site, on the topic of "Alternative Approaches for Risk Assessment". The overall aim is to provide comprehensive training on state-of-the-art alternative (non-animal) approaches to predictive toxicology and to promote their use within modern chemical risk assessment practice.
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calls

Call for experts to serve on EURL ECVAM's Scientific Advisory Committee (ESAC) Call for experts to serve on EURL ECVAM's Scientific Advisory Committee (ESAC) The European Union Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) is renewing membership of its EURL ECVAM Scientific Advisory Committee (ESAC). Interested scientific experts who satisfy the eligibility criteria and who possess the relevant competences are invited to apply (Deadline 31st January 2017).
EURL ECVAM extends the EU Network of Laboratories for the Validation of Alternative Methods (EU-NETVAL) EURL ECVAM extends the EU Network of Laboratories for the Validation of Alternative Methods (EU-NETVAL) Supporting the validation and implementation of in vitro methods for regulatory use
Horizon 2020 Call on New approaches to improve predictive human safety testing Horizon 2020 Call on New approaches to improve predictive human safety testing The role of JRC / EURL ECVAM in cooperating with successful consortia
Call for expressions of interest - EURL ECVAM Stakeholder forum (ESTAF) Open Invitation addressed to stakeholder organisations
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multimedia

Toxicological Testing of Chemicals & EURL ECVAM Toxicological Testing of Chemicals & EURL ECVAM Faces of Science - showcasing the human face of the scientific advice supporting EU policy. Maurice Whelan at the Joint Research Centre, the European Commission's in-house science service, presents the Toxicological Testing of Chemicals and EURL ECVAM
New EURL ECVAM video explains the validation process of alternative methods (in Italian) New EURL ECVAM video explains the validation process of alternative methods (in Italian) This video presents the European Union Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) and explains the validation process of alternative methods