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Our scientists show you what they are doing to advance safety assessment of chemicals without relying on animal testingdefault frame updated video

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The European Union Reference Laboratory for alternatives to animal testing (EURL-ECVAM) has been formally established in 2011, due to the increasing need for new methods to be developed and proposed for validation in the European Union. EURL ECVAM is hosted by the Joint Research Centre located in Ispra, Italy.

EURL ECVAM has a long tradition in the validation of methods which reduce, refine or replace the use of animals for safety testing and efficacy/potency testing of chemicals, biologicals and vaccines. Research laboratories are able to submit to EURL ECVAM for scientific validation the alternative methods to animal testing that they have developed.

EURL ECVAM also promotes the development and dissemination of alternative methods and approaches, their apEURL-ECVAMplication in industry and their acceptance by regulators.

The European Commission's involvement in activities targeted to the validation of alternative approaches to animal testing started in 1991, with the launch of ECVAM (the European Centre for the Validation of Alternative Methods), hosted by the Joint Research Centre. As from 2011, ECVAM's tasks are assigned to EURL ECVAM.Cell culture under sterile conditions-2

The menu on the left hand side of the page helps you browse through the main content sections of the EURL ECVAM web site.

To contact EURL ECVAM, please use this interactive form.

Photo: Cell culture under sterile conditions in the EURL ECVAM microbiology laboratory. Copyright EU 2012.

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highlights

EURL ECVAM's stakeholder forum and regulatory advisors share opinions on better knowledge sharing EURL ECVAM's stakeholder forum and regulatory advisors share opinions on better knowledge sharing - Dec 07, 2017 From the 27-29 November 2017, the annual meeting of EURL ECVAM's regulatory network (PARERE) and the joint meeting of PARERE and the ECVAM stakeholder forum (ESTAF) took place in Ispra. These meetings bring together stakeholder organisations representing academia, industry and civil society (including animal welfare NGOs) and regulators from a variety of sectors to reflect on how to progress alternative approaches to animal testing.
EURL ECVAM Status Report 2017 on alternative methods is now available EURL ECVAM Status Report 2017 on alternative methods is now available - Dec 04, 2017 The JRC hosted EU Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) has published its Status Report 2017 presenting an update on the development, validation and regulatory acceptance of alternative methods to animal testing.
Biologically based mathematical models in toxicology: current use and regulatory acceptance Biologically based mathematical models in toxicology: current use and regulatory acceptance - Nov 14, 2017 Scientists from the JRC and US Environmental Protection Agency examined how and to what extent mathematical models of biological organisms are used in toxicology, and identified a number of challenges that need to be overcome for wider use and regulatory acceptance of these non-animal approaches.
Human relevant in-vitro models for developmental neurotoxicity testing Human relevant in-vitro models for developmental neurotoxicity testing - Oct 17, 2017 JRC scientists have shown that human induced pluripotent stem cell-derived neurons are suitable non-animal models for testing neurotoxicity during brain development. The study revealed that long term exposure to the pesticide rotenone induces oxidative stress and can trigger neuronal cell death.
Knowledge sharing on in vitro methods: meeting of the EU Network of Laboratories for the Validation of Alternative Methods (EU-NETVAL) Knowledge sharing on in vitro methods: meeting of the EU Network of Laboratories for the Validation of Alternative Methods (EU-NETVAL) - Oct 13, 2017 EU-NETVAL is a large network of highly qualified test facilities across Europe, coordinated by the Joint Research Centre to support the in vitro method validation process. The annual meeting of this network took place on the 10-11th October 2017 to facilitate the sharing of expertise and practical knowledge for the advancement of in vitro methods to improve safety assessment and avoid animal testing.
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calls

Horizon 2020 Call on new testing and screening methods to identify endocrine disrupting chemicals Horizon 2020 Call on new testing and screening methods to identify endocrine disrupting chemicals JRC collaboration with successful consortia responding to the H2020 SC1-BHC-27-2018 Call on "New testing and screening methods to identify endocrine disrupting chemicals"
Call for Tender - Review of non-animal methods used in disease research Call for Tender - Review of non-animal methods used in disease research The JRC's EURL ECVAM has launched a study to collect and describe non-animal methods being used for basic and applied research into neurodegenerative, respiratory tract and cardiovascular diseases, and breast cancer.
Call for experts to serve on EURL ECVAM's Scientific Advisory Committee (ESAC) Call for experts to serve on EURL ECVAM's Scientific Advisory Committee (ESAC) The European Union Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) is renewing membership of its EURL ECVAM Scientific Advisory Committee (ESAC). Interested scientific experts who satisfy the eligibility criteria and who possess the relevant competences are invited to apply (Deadline 31st January 2017).
EURL ECVAM extends the EU Network of Laboratories for the Validation of Alternative Methods (EU-NETVAL) EURL ECVAM extends the EU Network of Laboratories for the Validation of Alternative Methods (EU-NETVAL) Supporting the validation and implementation of in vitro methods for regulatory use
Horizon 2020 Call on New approaches to improve predictive human safety testing Horizon 2020 Call on New approaches to improve predictive human safety testing The role of JRC / EURL ECVAM in cooperating with successful consortia
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multimedia

Toxicological Testing of Chemicals & EURL ECVAM Toxicological Testing of Chemicals & EURL ECVAM Faces of Science - showcasing the human face of the scientific advice supporting EU policy. Maurice Whelan at the Joint Research Centre, the European Commission's in-house science service, presents the Toxicological Testing of Chemicals and EURL ECVAM
New EURL ECVAM video explains the validation process of alternative methods (in Italian) New EURL ECVAM video explains the validation process of alternative methods (in Italian) This video presents the European Union Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) and explains the validation process of alternative methods