Featured article

skin structure

Review of the Availability of In Vitro and In Silico Methods for Assessing Dermal Bioavailability Read more...

 

Watch our video!

Our scientists show you what they are doing to advance safety assessment of chemicals without relying on animal testingdefault frame updated video

Transcripts: pdf icon EN; FR; DE; IT.

The European Union Reference Laboratory for alternatives to animal testing (EURL-ECVAM) has been formally established in 2011, due to the increasing need for new methods to be developed and proposed for validation in the European Union. EURL ECVAM is hosted by the Joint Research Centre located in Ispra, Italy.

EURL ECVAM has a long tradition in the validation of methods which reduce, refine or replace the use of animals for safety testing and efficacy/potency testing of chemicals, biologicals and vaccines. Research laboratories are able to submit to EURL ECVAM for scientific validation the alternative methods to animal testing that they have developed.

EURL ECVAM also promotes the development and dissemination of alternative methods and approaches, their apEURL-ECVAMplication in industry and their acceptance by regulators.

The European Commission's involvement in activities targeted to the validation of alternative approaches to animal testing started in 1991, with the launch of ECVAM (the European Centre for the Validation of Alternative Methods), hosted by the Joint Research Centre. As from 2011, ECVAM's tasks are assigned to EURL ECVAM.Cell culture under sterile conditions-2

The menu on the left hand side of the page helps you browse through the main content sections of the EURL ECVAM web site.

To contact EURL ECVAM, please use this interactive form.

Photo: Cell culture under sterile conditions in the EURL ECVAM microbiology laboratory. Copyright EU 2012.

RSS

highlights

Human stem cell models for neurotoxicity screening Human stem cell models for neurotoxicity screening - Jun 12, 2017 JRC scientists have shown human induced pluripotent stem cell (hiPSC) to be a promising in vitro model for neurotoxicity testing. These stem cell-based systems offer an innovative human-relevant alternative to traditional animal tests that can improve the efficacy of drug discovery and support safety assessment.
Two new guidelines for the reduction of animal tests for quality control of veterinary vaccines Two new guidelines for the reduction of animal tests for quality control of veterinary vaccines - May 31, 2017 JRC scientists supported the development of two guidelines released by the International Cooperation on Harmonisation of Technical Requirements for Registration of Veterinary Medicinal Products (VICH) on the harmonisation of criteria to waive target animal batch safety tests for inactivated and live veterinary vaccines. Their implementation (from May 2018 onwards) is a major step towards international harmonisation and will reduce the number of animals used for batch release testing. The JRC's EU Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) has been working on behalf of EMA with VICH experts on the development of these guidelines.
JRC Summer School on Alternative Approaches for Risk Assessment JRC Summer School on Alternative Approaches for Risk Assessment - May 24, 2017 From 16 to 19 May, the JRC hosted in Ispra (Italy) 101 postgraduate students and early-career scientists from 29 countries worldwide for the JRC Summer School on Alternative Approaches for Risk Assessment.
Reducing animal testing while improving the safety assessment of chemicals for skin allergies Reducing animal testing while improving the safety assessment of chemicals for skin allergies - May 03, 2017 The JRC's European Union Reference Laboratory for alternatives to animal testing (EURL ECVAM) has published its recommendation on the use of non-animal approaches for skin sensitisation (allergy) testing. This document builds on the progress made in the area since the publication of the EURL ECVAM strategy in 2013 and provides EURL ECVAM views on the latest two methods for skin sensitisation, the LuSens and the U-SENS™, peer-reviewed by the EURL ECVAM Scientific Advisory Committee (ESAC) and on Defined Approaches which are based on the integration of different kinds of non-animal data.
JRC hosts a meeting to strengthen its collaboration with the European Food Safety Authority (EFSA) JRC hosts a meeting to strengthen its collaboration with the European Food Safety Authority (EFSA) - Apr 10, 2017 On 5th April JRC-Ispra hosted a delegation from EFSA to discuss specific topics of common interest in the area of risk assessment related to chemicals.
RSS

calls

Call for experts to serve on EURL ECVAM's Scientific Advisory Committee (ESAC) Call for experts to serve on EURL ECVAM's Scientific Advisory Committee (ESAC) The European Union Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) is renewing membership of its EURL ECVAM Scientific Advisory Committee (ESAC). Interested scientific experts who satisfy the eligibility criteria and who possess the relevant competences are invited to apply (Deadline 31st January 2017).
EURL ECVAM extends the EU Network of Laboratories for the Validation of Alternative Methods (EU-NETVAL) EURL ECVAM extends the EU Network of Laboratories for the Validation of Alternative Methods (EU-NETVAL) Supporting the validation and implementation of in vitro methods for regulatory use
Horizon 2020 Call on New approaches to improve predictive human safety testing Horizon 2020 Call on New approaches to improve predictive human safety testing The role of JRC / EURL ECVAM in cooperating with successful consortia
Call for expressions of interest - EURL ECVAM Stakeholder forum (ESTAF) Open Invitation addressed to stakeholder organisations
RSS

multimedia

Toxicological Testing of Chemicals & EURL ECVAM Toxicological Testing of Chemicals & EURL ECVAM Faces of Science - showcasing the human face of the scientific advice supporting EU policy. Maurice Whelan at the Joint Research Centre, the European Commission's in-house science service, presents the Toxicological Testing of Chemicals and EURL ECVAM
New EURL ECVAM video explains the validation process of alternative methods (in Italian) New EURL ECVAM video explains the validation process of alternative methods (in Italian) This video presents the European Union Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) and explains the validation process of alternative methods