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Our scientists show you what they are doing to advance safety assessment of chemicals without relying on animal testingdefault frame updated video

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The European Union Reference Laboratory for alternatives to animal testing (EURL-ECVAM) has been formally established in 2011, due to the increasing need for new methods to be developed and proposed for validation in the European Union. EURL ECVAM is hosted by the Joint Research Centre located in Ispra, Italy.

EURL ECVAM has a long tradition in the validation of methods which reduce, refine or replace the use of animals for safety testing and efficacy/potency testing of chemicals, biologicals and vaccines. Research laboratories are able to submit to EURL ECVAM for scientific validation the alternative methods to animal testing that they have developed.

EURL ECVAM also promotes the development and dissemination of alternative methods and approaches, their apEURL-ECVAMplication in industry and their acceptance by regulators.

The European Commission's involvement in activities targeted to the validation of alternative approaches to animal testing started in 1991, with the launch of ECVAM (the European Centre for the Validation of Alternative Methods), hosted by the Joint Research Centre. As from 2011, ECVAM's tasks are assigned to EURL ECVAM.Cell culture under sterile conditions-2

The menu on the left hand side of the page helps you browse through the main content sections of the EURL ECVAM web site.

To contact EURL ECVAM, please use this interactive form.

Photo: Cell culture under sterile conditions in the EURL ECVAM microbiology laboratory. Copyright EU 2012.

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highlights

JRC's EURL ECVAM publishes new Opinions from its Scientific Advisory Committee, ESAC JRC's EURL ECVAM publishes new Opinions from its Scientific Advisory Committee, ESAC - Dec 01, 2016 The EURL ECVAM's Scientific Advisory Committee (ESAC) Opinions published by the Joint Research Centre's EURL ECVAM (the European Union Reference Laboratory for Alternatives to Animal Testing) are the outcome of the scientific peer review of five validation studies on alternative methods for skin sensitisation, skin irritation and serious eye damage/eye irritation.
Collaborative workshop to explore regulatory use of non-animal approaches in chemical safety assessment Collaborative workshop to explore regulatory use of non-animal approaches in chemical safety assessment - Nov 21, 2016 On the 9-10 November the JRC's EU Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) hosted a workshop to explore the possible regulatory use of alternative (non-animal) approaches to systemic toxicity that are intended for the hazard and safety assessment of chemicals used in a variety of sectors.
EURL ECVAM meets with its networks of regulators and stakeholders EURL ECVAM meets with its networks of regulators and stakeholders - Nov 21, 2016 On the 8th of November the JRC's EU Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) hosted a meeting of its network for the Preliminary Assessment of Regulatory Relevance (PARERE) of alternative methods, followed by a joint meeting of PARERE and the EURL ECVAM Stakeholder Forum (ESTAF).
Computational modelling of estrogen active substances: results of a large-scale international research project Computational modelling of estrogen active substances: results of a large-scale international research project - Nov 16, 2016 The JRC contributed to a large-scale modelling project led by the US Environmental Protection Agency (EPA) that demonstrated the usefulness of computational models in screening thousands of environmental chemicals for their ability to bind to the estrogen receptor. Chemicals that bind to the estrogen receptor may interfere with the biological effects of the natural hormone estrogen, potentially leading to adverse effects on both humans and wildlife.
JRC's EURL ECVAM publishes it latest Status Report JRC's EURL ECVAM publishes it latest Status Report - Nov 15, 2016 The Status Report 2016 published by the Joint Research Centre's EURL ECVAM (the European Union Reference Laboratory for Alternatives to Animal Testing) provides an update on the development, validation, dissemination and regulatory acceptance of alternative approaches, building on the last status report published in September 2015.
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events

European Commission Scientific Conference: Non-Animal Approaches - The Way Forward - Dec 06, 2016 - Dec 07, 2016 On 6-7th December 2016, the European Commission will hold a scientific conference in Brussels to engage the scientific community and relevant stakeholders in a debate on how to exploit cutting edge advances in biomedical and other research in the development of scientifically valid non-animal approaches (alternatives to animal testing).
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calls

EURL ECVAM extends the EU Network of Laboratories for the Validation of Alternative Methods (EU-NETVAL) EURL ECVAM extends the EU Network of Laboratories for the Validation of Alternative Methods (EU-NETVAL) Supporting the validation and implementation of in vitro methods for regulatory use
Horizon 2020 Call on New approaches to improve predictive human safety testing Horizon 2020 Call on New approaches to improve predictive human safety testing The role of JRC / EURL ECVAM in cooperating with successful consortia
Call for expressions of interest - EURL ECVAM Stakeholder forum (ESTAF) Open Invitation addressed to stakeholder organisations
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multimedia

Toxicological Testing of Chemicals & EURL ECVAM Toxicological Testing of Chemicals & EURL ECVAM Faces of Science - showcasing the human face of the scientific advice supporting EU policy. Maurice Whelan at the Joint Research Centre, the European Commission's in-house science service, presents the Toxicological Testing of Chemicals and EURL ECVAM
New EURL ECVAM video explains the validation process of alternative methods (in Italian) New EURL ECVAM video explains the validation process of alternative methods (in Italian) This video presents the European Union Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) and explains the validation process of alternative methods